16+
Major trials tracked
KRAS inhibitors · Live ClinicalTrials.gov data
Sotorasib (Lumakras) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 sotorasib trials on ClinicalTrials.gov by enrolment, 6 of them actively recruiting. The next phase 3 primary completion among them is expected Jun 2027. Refreshed daily — add up to four competitors to compare pipelines side by side.
5
Phase 3 trials
6
Actively recruiting
Jun 2027
Next phase 3 primary completion
5,856
Participants across trials
Amgen
Lead sponsor by trial count
sotorasib (16)14 active2020–2032
sotorasib
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sotorasib
Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).P3
CodeBreaK201P2
CodeBreak300P3
SOLUCOMP2
breakthroughP2
CODEBREAK-IGRP2
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening TrialP2
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)P2
A Phase 2 Basket Trial in Which Patients With Advanced Solid Tumors Carrying the KRAS G12C mUtation Receive Treatment With a Combination of Sotorasib and PanitumumabP2
A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)P3
CodeBreaK 301P3
Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)P2
A Study of Sotorasib in People With Non-Small Cell Lung CancerP2
Krascendo 1P3
COLOSOTOP2
CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung CancerP2
Upcoming readouts
8 ahead · sotorasib
Select a trial to load its full ClinicalTrials.gov record.
Key sotorasib trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT05920356 | A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as… | Phase 3 | Recruiting | Jun 2027 |
| NCT06252649 | CodeBreaK 301 — Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve… | Phase 3 | Recruiting | Sept 2028 |
| NCT04303780 | Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBr… | Phase 3 | Active, not recruiting | Aug 2022 |
| NCT06497556 | Krascendo 1 — A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Pre… | Phase 3 | Active, not recruiting | May 2026 |
| NCT05198934 | CodeBreak300 — Sotorasib and Panitumumab Versus Investigator's Choice for Participants With Kirsten Rat Sarcoma (KRAS) p.G12C… | Phase 3 | Completed | Jul 2025 |
| NCT05845450 | Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN) | Phase 2 | Recruiting | May 2026 |
| NCT06582771 | A Study of Sotorasib in People With Non-Small Cell Lung Cancer | Phase 2 | Recruiting | Aug 2026 |
| NCT05631249 | CODEBREAK-IGR — Sotorasib in Previously Treated Locally Advanced or Metastatic NSCLC Subjects With Mutated KRAS p.G12C | Phase 2 | Recruiting | Dec 2027 |
| NCT05564377 | Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumo… | Phase 2 | Recruiting | Jul 2030 |
| NCT05638295 | Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumo… | Phase 2 | Active, not recruiting | Dec 2028 |
| NCT07543172 | CIMAvax-EGF With KRAS G12C Inhibitor for the Treatment of Advanced, KRAS G12C Mutated Non Small Cell Lung Canc… | Phase 2 | Not yet recruiting | Jun 2029 |
| NCT07124884 | COLOSOTO — 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Pat… | Phase 2 | Not yet recruiting | Jun 2030 |
Related drug pipelines
FAQ
- How many clinical trials are running for sotorasib?
- ClinicalTrials.gov lists more than 16 phase 2–4 sotorasib trials. This page tracks the 16 largest by enrolment: 11 phase 2, 5 phase 3, and 0 phase 4 among them, with 6 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare sotorasib against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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