Big pharma · NVS · 4,357 trials led

Novartis clinical trial pipeline

4,357 trials as lead sponsor, 188 recruiting now, 1,270 in phase 3. Live from ClinicalTrials.gov, updated daily.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
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Archive historyOct 2022 to Sept 2026

149 recorded changes across Novartis trials

Every status move, completion date shift and enrollment change ComplyRx has recorded across 36 of these trials. One is shown below.

Status changeStatus moved to recruiting from not yet recruitingNCT07801508 · recorded 9 Sept 2026
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+145 more recorded changes · Track a drug to see every change the night it lands

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Most active programmes

The drugs appearing most often across Novartis's recently active trials. Comparator arms are excluded.

  • Remibrutinib7 trials
  • Ianalumab4 trials
  • trametinib3 trials
  • Ruxolitinib3 trials
  • 68Ga-PSMA-113 trials
  • Fulvestrant3 trials

Upcoming readouts

Next primary completion dates among Novartis's active phase 2 and phase 3 trials. Dates are registry estimates and move often, which is exactly what the tracker watches.

Top therapeutic areas

Conditions studied most often across Novartis's recently active trials.

  • Breast Cancer3 trials
  • Primary Myelofibrosis (PMF)2 trials
  • Sickle Cell Disease2 trials
  • Chagas Disease2 trials
  • Primary Immune Thrombocytopenia (ITP)2 trials
  • Prostate Cancer2 trials

Novartis pipeline by phase

The main study drugs across 315 active trials Novartis leads on ClinicalTrials.gov. Each drug sits in the highest phase among its currently active trials, which can be lower than a phase it has already completed.

Phase 331 drugs

Novartis phase 3 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
IanalumabVAY736176Oct 2026 est.NCT07621809 · NCT06711887 · NCT06133972
Remibrutinib167Nov 2026 est.NCT07816328 · NCT07811869 · NCT07768371
IptacopanLNP023139Dec 2026 est.NCT06994845 · NCT06934967 · NCT06517758
Alpelisib92Jan 2027 est.NCT05038735 · NCT04208178 · NCT07679269
Pelabresib74Nov 2026 est.NCT07357727 · NCT06401356 · NCT04603495
Pelacarsen64Feb 2028 est.NCT07625306 · NCT07517263 · NCT06875973
OpnurasibJDQ44351Sept 2026 est.NCT05132075 · NCT05445843 · NCT07468071
TisagenlecleucelCTL01953Mar 2027 est.NCT05888493 · NCT04094311 · NCT03876769
Lutathera4Mar 2028 est.NCT03972488 · NCT04711135 · NCT05142696
Asciminib3NCT05456191 · NCT04971226 · NCT05384587
ZigakibartBION-130132Aug 2027 est.NCT06858319 · NCT05852938 · NCT07146906
AAA81722Jun 2028 est.NCT06855277 · NCT06780670
Apraclonidine Ophthalmic Solution, 0.125% Unit Dose Preservative Free2Jan 2027 est.NCT07578363 · NCT07531043
Atrasentan2Apr 2028 est.NCT04573478 · NCT04573920
Inclisiran sodium 300 mg2Oct 2026 est.NCT05360446 · NCT05030428
NIO75221Jul 2029 est.NCT07498426 · NCT05469360
Remibrutinib (Blinded)22Feb 2028 est.NCT07225504 · NCT06744920
Abelacimab1Dec 2030 est.NCT07739888
Crizanlizumab (SEG101)1NCT03814746
Drug: Atrasentan11Sept 2031 est.NCT07498335
inclisiran sodium1NCT04765657
Inclisiran sodium 300 mg (equivalent to 284 mg inclisiran) in 1.5 mL1Apr 2029 est.NCT05739383
Octreotide LAR11Dec 2028 est.NCT06784752
Ofatumumab new dose1NCT06869785
onasemnogene abeparvovec1Apr 2031 est.NCT05335876
Onasemnogene Abeparvovec-xioi1Dec 2035 est.NCT04042025
Previously treated CAR-T patients11Feb 2036 est.NCT02445222
QMF14911Feb 2028 est.NCT05562466
QVM14911Dec 2028 est.NCT05776927
Remibrutinib oral treatment11Jul 2029 est.NCT06846281
Votoplam (blinded)11Apr 2030 est.NCT07326709

Phase 230 drugs

Novartis phase 2 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Rapcabtagene autoleucelYTB3237Sept 2026 est.NCT06868290 · NCT06665256 · NCT06655896
GIA63232May 2027 est.NCT07775924 · NCT07431177 · NCT07220577
JSB4623Jan 2027 est.NCT07047118 · NCT06991556 · NCT07174063
QCZ48432Jan 2027 est.NCT07610278 · NCT07543120 · NCT06857955
DDY39121Dec 2028 est.NCT07801495 · NCT07737743
MAS82521Apr 2027 est.NCT07203001 · NCT04641442
PKN60521Feb 2027 est.NCT07217067 · NCT07797322
VHB93721Sept 2028 est.NCT07094516 · NCT06643481
ABL001/Asciminib11Feb 2029 est.NCT06514534
Arumakimig1Dec 2028 est.NCT07748624
Capmatinib1Jul 2027 est.NCT03040973
CFZ5331NCT03827798
Cryptosporidium parvum oocysts (ABO809)11Mar 2027 est.NCT07249463
decitabine1Feb 2028 est.NCT05201066
DII2351Apr 2027 est.NCT07235046

Phase 146 drugs

Novartis phase 1 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
PIT5653Jan 2027 est.NCT07029555 · NCT06335979 · NCT05397496
[68Ga]Ga-DWJ15522Jun 2028 est.NCT07801508 · NCT07117214
[68Ga]Ga-NeoB2Dec 2026 est.NCT06247995 · NCT05870579
rapcabtagene autoleucel (YTB323)2Jun 2030 est.NCT06675864 · NCT06617793
Tulmimetostat22Feb 2030 est.NCT07190300 · NCT04104776
[177Lu]Lu-DWJ15511May 2032 est.NCT07660055
[177Lu]Lu-NeoB1Nov 2028 est.NCT05739942
[68Ga]Ga-NNS30911Jan 2031 est.NCT06562192
[68Ga]Ga-PSMA-111NCT06379217
225^Ac-PSMA-6171Jan 2027 est.NCT04597411

Phase 421 drugs

Novartis phase 4 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
inclisiran116Oct 2026 est.NCT07684469 · NCT07102628 · NCT06597019
177Lu-PSMA-617AAA61793Oct 2026 est.NCT05803941 · NCT05939414 · NCT04720157
RibociclibLEE01194Feb 2027 est.NCT05161195 · NCT05827081 · NCT03701334
Secukinumab42Feb 2028 est.NCT07489573 · NCT05622708 · NCT06331312
dabrafenib31Nov 2026 est.NCT03975829 · NCT03340506 · NCT04940052
Ofatumumab3Apr 2027 est.NCT05090371 · NCT04926818 · NCT03650114
Ruxolitinib31May 2029 est.NCT06824103 · NCT06462469 · NCT02386800
Asciminib single agent22Aug 2030 est.NCT04877522 · NCT07354074

Derived from 315 active trials Novartis leads; 286 name an intervention, folding into 128 phased drugs. 12 interventions carry no registry phase (observational studies, tests and devices) and are not shown. This is ComplyRx's reading of the registry, not Novartis's own pipeline disclosure.

Novartis trials

The 50 most significant of Novartis's recently active trials, soonest estimated readout first.
Select any row for the full record; the change timeline unlocks with tracking.

TrialPhaseStabilityStatusEnrollmentEst. readout
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection FractionNCT07465653HJB647 low dosePhase 1Locked · track to revealOngoingRecruiting12 est.24 Sept 2026
A Real-World Study of Ofatumumab in Multiple Sclerosis Patients in Germany and JapanNCT07821411Not yet scoredOngoingActive, not recruiting5,000 est.30 Sept 2026
Feasibility Study of an Accommodating IOL DesignNCT07147192AAL-FAIOLNaLocked · track to revealOngoingActive, not recruiting85 est.Oct 2026
Pediatric Long-Term Follow-up and Rollover StudyNCT03975829dabrafenibPhase 4Locked · track to revealOngoingActive, not recruiting163 est.5 Nov 2026
Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) DesignNCT05317728BAL-FAIOL IOLNaLocked · track to revealOngoingActive, not recruiting175 est.Nov 2026
SMA-REALA Real-World Medical Chart Review of Spinal Muscular Atrophy Patients Treated With Onasemnogene Abeparvovec in Saudi ArabiaNCT07737756Not yet scoredOngoingNot yet recruiting6 est.20 Nov 2026
ROUTE-C3GA Study of Complement 3 Glomerulopathy (C3G) Patients Treated With Iptacopan Through an Early Access Program in SpainNCT07598448Not yet scoredOngoingNot yet recruiting35 est.15 Dec 2026
PSMACareA Phase II Study of AAA617 Alone and AAA617 in Combination With ARPI in Patients With PSMA PET Scan Positive CRPCNCT05849298AAA617Phase 2Locked · track to revealOngoingActive, not recruiting49 est.23 Dec 2026
[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast CancerNCT05870579[68Ga]Ga-NeoBPhase 1Locked · track to revealOngoingActive, not recruiting28 est.30 Dec 2026
ScreenXModifying PEST for Psoriatic Arthritis ScreeningNCT06382051PEST Screening groupNaLocked · track to revealOngoingRecruiting502 est.31 Dec 2026
Agreement of Two OCT Biometers: A Pilot StudyNCT07782619UNITY DXNot yet scoredOngoingRecruiting50 est.Jan 2027
An Investigation of FID 123472 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness in AdultsNCT07578363Apraclonidine Ophthalmic Solution, 0.125% Unit Dose Preservative FreePhase 3Locked · track to revealOngoingNot yet recruiting178 est.Jan 2027
EPIK-B5Study to Assess the Efficacy and Safety of Alpelisib Plus Fulvestrant in Participants With HR-positive (HR+), HER2-negative, Advanced Breast Cancer After Treatment With a CDK4/6 Inhibitor and an Aromatase Inhibitor.NCT05038735AlpelisibPhase 3Locked · track to revealOngoingActive, not recruiting210 est.28 Jan 2027
A Study to Identify an Optimal Dose of QCZ484 in Mild to Moderate Hypertensive PatientsNCT06857955QCZ484Phase 2Locked · track to revealOngoingActive, not recruiting396 est.29 Jan 2027
Dose Optimization and Expansion Study of DFV890 in Adult Patients With Myeloid DiseasesNCT05552469DFV890Phase 1Locked · track to revealOngoingActive, not recruiting71 est.1 Feb 2027
PLATINUMPlatform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Participants With Uncomplicated Plasmodium Falciparum Malaria (Cohort C2)NCT07811908KAE609Phase 2Not yet scoredOngoingRecruiting120 est.4 Feb 2027
ACSEvaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary SyndromesNCT07102628InclisiranPhase 3Locked · track to revealOngoingRecruiting300 est.11 Feb 2027
Efficacy and Safety of FID 123472 Ophthalmic Solution for Ocular Redness in AdultsNCT07531043Apraclonidine Ophthalmic Solution, 0.125% Unit Dose Preservative FreePhase 3Locked · track to revealOngoingNot yet recruiting230 est.Feb 2027
A Study to Investigate the Pharmacokinetics and Safety of PKN605 in Participants With Moderate and Severe Renal Impairment Compared to Matched Control Subjects With Normal Renal FunctionNCT07797322PKN605Phase 1Not yet scoredOngoingNot yet recruiting40 est.18 Feb 2027
Study of Out of Specification for TisagenlecleucelNCT04094311CTL019Phase 3Locked · track to revealOngoingRecruiting200 est.31 Mar 2027
NeoB-Cap1A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/6 Inhibitor.NCT06247995[68Ga]Ga-NeoBPhase 1Locked · track to revealOngoingActive, not recruiting20 est.14 Apr 2027
A Phase II Trial to Evaluate the Clinical Efficacy, Safety and Tolerability of MAS825 in Pediatric and Adult Participants With Still's DiseaseNCT07203001MAS825Phase 2Locked · track to revealOngoingRecruiting30 est.22 Apr 2027
A Study to Assess the Efficacy, Safety and Pharmacokinetics of EYU688 in Patients With Dengue FeverNCT06006559EYU688Phase 2Locked · track to revealOngoingRecruiting108 est.22 Jul 2027
A Study of Efficacy, Safety, Tolerability of LXE408 in Participants With Chronic Chagas Disease.NCT06632600LXE408Phase 2Locked · track to revealOngoingRecruiting130 est.22 Jul 2027
A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic SclerosisNCT06470048IanalumabPhase 2Locked · track to revealOngoingRecruiting200 est.30 Jul 2027
Study to Allow Patients Previously Participating in a Novartis Sponsored Trial to Continue Receiving Capmatinib Treatment as Single Agent or in Combination With Other Treatments or the Combination Treatment AloneNCT03040973CapmatinibPhase 2Locked · track to revealOngoingActive, not recruiting29 est.30 Jul 2027
REAL-HTNA Real-world Study of the Effectiveness of Angiotensin Receptor-Neprilysin Inhibitor Therapy in Hypertensive Patients in the United Arab EmiratesNCT07465666Not yet scoredOngoingNot yet recruiting500 est.15 Aug 2027
Study of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic UrticariaNCT06865651RemibrutinibPhase 2Locked · track to revealOngoingRecruiting44 est.23 Aug 2027
Study to Determine the Dose and Safety of Asciminib in Pediatric Patients With Chronic Myeloid LeukemiaNCT04925479Asciminib Pediatric formulation groupPhase 1Locked · track to revealOngoingRecruiting34 est.21 Sept 2027
A Study of Clinical Practice and Real-world Care of Patients Treated With mTOR, PI3K, and MEK Inhibitors for Extracranial Vascular AnomaliesNCT07767877Not yet scoredOngoingNot yet recruiting200 est.29 Oct 2027
A Phase 2 Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib (LOU064) in Adult Patients With Papulopustular Rosacea (PPR)NCT07681271LOU064Phase 2Not yet scoredOngoingRecruiting100 est.7 Dec 2027
A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)NCT06581198rapcabtagene autoleucelPhase 2Locked · track to revealOngoingActive, not recruiting179 est.14 Feb 2028
PSMA-DCAn Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.NCT05939414AAA617Phase 3Locked · track to revealOngoingRecruiting450 est.25 Apr 2028
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell DiseaseNCT06546670ITU512Phase 1Locked · track to revealOngoingRecruiting161 est.1 May 2028
VAY2EXPLOREA Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)NCT07421167ianalumabPhase 2Locked · track to revealOngoingRecruiting164 est.9 May 2028
MANIFEST-3A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)NCT07357727PelabresibPhase 3Locked · track to revealOngoingRecruiting460 est.17 May 2028
VITESSA Phase IIb Dose-ranging Study to Assess the Efficacy and Safety of GIA632 in Participants With Non-segmental VitiligoNCT07431177GIA632Phase 2Locked · track to revealOngoingRecruiting210 est.6 Jun 2028
A Study of [68Ga]Ga-DWJ155 in Adult Patients With Solid TumorsNCT07801508[68Ga]Ga-DWJ155Phase 1Locked · track to revealOngoingRecruiting66 est.30 Jun 2028
Investigation of a Remibrutinib- and Omalizumab-based Treatment Algorithm in Adult Patients With Chronic Spontaneous Urticaria Inadequately Controlled by H1-antihistamines Within 24 WeeksNCT07816328RemibrutinibPhase 3Not yet scoredOngoingNot yet recruiting382 est.17 Jul 2028
EPIK-P4: A Phase II Single-arm Study to Assess the Efficacy, Safety and Pharmacokinetics of Alpelisib (BYL719) in Pediatric and Adult Patients With PIK3CA-related Overgrowth Spectrum (PROS)NCT06997588AlpelisibPhase 2Locked · track to revealOngoingRecruiting104 est.2 Aug 2028
AcTFirstStudy Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPCNCT06855277AAA817Phase 3Locked · track to revealOngoingRecruiting940 est.29 Sept 2028
Specified Drug-use Surveillance of Fabhalta CapsulesNCT06606314Not yet scoredOngoingActive, not recruiting132 est.30 Sept 2028
A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's DiseaseNCT07048197Rapcabtagene autoleucelPhase 1Locked · track to revealOngoingActive, not recruiting27 est.1 Nov 2028
ELIPSIA Study to Assess the Efficacy and Safety of GIA632 Across a Range of Doses in Participants With Moderate to Severe Cutaneous Lichen PlanusNCT07775924GIA632Phase 2Not yet scoredOngoingRecruiting259 est.22 Nov 2028
Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Diffuse Cutaneous Systemic SclerosisNCT06655896rapcabtagene autoleucelPhase 2Locked · track to revealOngoingActive, not recruiting96 est.30 Nov 2028
NETTER-3Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NETNCT06784752[177Lu]Lu-DOTA-TATEPhase 3Locked · track to revealOngoingRecruiting240 est.8 Dec 2028
A Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic ArthritisNCT07801495DDY391Phase 2Not yet scoredOngoingNot yet recruiting220 est.13 Dec 2028
A Study to Evaluate the Efficacy and Safety of QVM149 (Indacaterol Acetate / Glycopyrronium Bromide / Mometasone Furoate) Versus Salmeterol Xinafoate/Fluticasone Propionate in Children From 12 Years to Less Than 18 Years of Age With Asthma.NCT05776927QVM149Phase 3Locked · track to revealOngoingRecruiting188 est.30 Dec 2028
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's DiseaseNCT07737743DDY391Phase 2Locked · track to revealOngoingRecruiting344 est.19 Feb 2029
A Study to Evaluate Efficacy, Safety, and Tolerability of Remibrutinib in Adult Participants With Severe Chronic Pruritus of Unknown Origin (CPUO)NCT07811869RemibrutinibPhase 3Not yet scoredOngoingRecruiting180 est.26 Feb 2029
View all trials4,357

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We check every one of its trials daily and tell you what moved.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
US registryClinicalTrials.gov
EU registryCTIS · Soon
4,357

Trials as lead sponsor

188

Recruiting now

1,270

Phase 3 trials

1,145

Phase 2 trials

667

Phase 1 trials

648

Phase 4 trials