Big pharma · AZN · 4,054 trials led

AstraZeneca clinical trial pipeline

4,054 trials as lead sponsor, 263 recruiting now, 905 in phase 3. Live from ClinicalTrials.gov, updated daily.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
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Archive historyOct 2023 to Sept 2026

71 recorded changes across AstraZeneca trials

Every status move, completion date shift and enrollment change ComplyRx has recorded across 27 of these trials. One is shown below.

Status changeStatus moved to recruiting from not yet recruitingNCT07646600 · recorded 16 Sept 2026
Track to read them

+67 more recorded changes · Track a drug to see every change the night it lands

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Most active programmes

The drugs appearing most often across AstraZeneca's recently active trials. Comparator arms are excluded.

  • Anifrolumab5 trials
  • Ravulizumab4 trials
  • Acalabrutinib4 trials
  • Durvalumab4 trials
  • Surovatamig4 trials
  • Elecoglipron4 trials

Upcoming readouts

Next primary completion dates among AstraZeneca's active phase 2 and phase 3 trials. Dates are registry estimates and move often, which is exactly what the tracker watches.

Top therapeutic areas

Conditions studied most often across AstraZeneca's recently active trials.

  • Systemic Lupus Erythematosus7 trials
  • Asthma5 trials
  • Breast Cancer5 trials
  • Lung Cancer3 trials
  • Dilated Cardiomyopathy2 trials
  • Heart Failure2 trials

AstraZeneca pipeline by phase

The main study drugs across 444 active trials AstraZeneca leads on ClinicalTrials.gov. Each drug sits in the highest phase among its currently active trials, which can be lower than a phase it has already completed.

Phase 359 drugs

AstraZeneca phase 3 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Durvalumab392Sept 2026 est.NCT06992609 · NCT06960577 · NCT05943106
Datopotamab deruxtecan125Sept 2026 est.NCT07720284 · NCT07205822 · NCT06564844
VolrustomigMEDI5752124Oct 2026 est.NCT06129864 · NCT06097728 · NCT06079671
RilvegostomigAZD2936119Jul 2027 est.NCT07221253 · NCT06868277 · NCT06764875
Tezepelumab116Jan 2027 est.NCT07520162 · NCT07363642 · NCT06883305
Elecoglipron109Oct 2026 est.NCT07775404 · NCT07761117 · NCT07753993
Osimertinib102Feb 2027 est.NCT06350097 · NCT05629234 · NCT05120349
AZD012087Oct 2027 est.NCT07764978 · NCT07735637 · NCT07391657
AZD623484Feb 2027 est.NCT07784725 · NCT07784270 · NCT07776509
CamizestrantAZD983383Apr 2027 est.NCT07647328 · NCT05952557 · NCT05774951
SaruparibAZD530583Oct 2026 est.NCT07711002 · NCT06952803 · NCT06380751
SurovatamigAZD048688Feb 2028 est.NCT07509151 · NCT07215585 · NCT06549595
Capivasertib61Oct 2026 est.NCT06635447 · NCT05348577 · NCT04862663
SelumetinibAZD62445NCT04924608 · NCT01933932 · NCT05101148
Sonesitatug VedotinAZD090153Sept 2026 est.NCT07431281 · NCT06346392 · NCT07143604
AZD078041Sept 2026 est.NCT07000357 · NCT07000136 · NCT07000123
Ceralasertib4NCT05450692 · NCT05941897 · NCT05061134
Savolitinib4Jan 2027 est.NCT05261399 · NCT05043090 · NCT03091192
Tremelimumab41Mar 2030 est.NCT06921785 · NCT05301842 · NCT02519348
ALXN18503NCT06079372 · NCT06079359 · NCT06079281
Baxdrostat/dapagliflozin31Dec 2026 est.NCT06742723 · NCT06268873 · NCT07222917
Datopotamab Deruxtecan (Dato-DXd)32Oct 2027 est.NCT07291037 · NCT05489211 · NCT05460273
Fulvestrant3Dec 2027 est.NCT06764186 · NCT04305496 · NCT00099437
Tozorakimab33Jun 2027 est.NCT07566195 · NCT05624450 · NCT06932263
ALXN22202Dec 2027 est.NCT07789483 · NCT06183931
Anifrolumab (blinded)21Jan 2027 est.NCT06455449 · NCT05925803
AZD533522Oct 2027 est.NCT07218809 · NCT07402915
Balcinrenone/dapagliflozin21Dec 2026 est.NCT07624305 · NCT07754331
CAEL-1012NCT04512235 · NCT04504825
Danicopan21May 2027 est.NCT06449001 · NCT05389449
Durvalumab (MEDI4736)2NCT03528694 · NCT03003962
Eplontersen2Feb 2029 est.NCT06194825 · NCT07608354
laroprovstat/rosuvastatin 121May 2027 est.NCT07619131 · NCT07619118
Monalizumab2NCT04590963 · NCT02671435
Olaparib 300mg tablets2NCT01874353 · NCT01844986
Torvutatug samrotecan21Aug 2028 est.NCT07816666 · NCT05797168
Zibotentan/Dapagliflozin2Sept 2026 est.NCT06087835 · NCT06942910
Actinium (225Ac) zadavotide guraxetan (AZD2265 [FPI-2265])11Jun 2029 est.NCT07611110
ALXN17201NCT05556096
AZD9291 80 mg/40 mg1NCT02511106
Baxdrostat11Aug 2027 est.NCT07007793
baxdrostat 2mg1Feb 2028 est.NCT07686120
Baxdrostat and dapagliflozin11Dec 2029 est.NCT06677060
BDA MDI11Oct 2027 est.NCT06307665
Bevacizumab1NCT03737643
BGF MDI 320/14.4/9.6 μg11Dec 2027 est.NCT06283966
Budesonide/Albuterol metered dose inhaler, MDI11Oct 2027 est.NCT06471257
Durvalumab + Chemotherapy phase1Nov 2028 est.NCT06746116
Durvalumab +Tremelimumab1NCT02542293
eculizumab1Dec 2026 est.NCT06724809
eneboparatide1NCT05778071
Gefurulimab11Dec 2026 est.NCT06607627
ICS-LABA11Nov 2028 est.NCT06750289
Nexium 20mg1NCT05267613
Osimertinib (AZD9291) pemetrexed cisplatin or carboplatin1NCT04765059
Osimertinib 80mg/40mg1NCT03521154
Pemetrexed/Carboplatin1NCT04035486
Puxitatug Samrotecan11Oct 2027 est.NCT07044336
Sodium Zirconium Cyclosilicate (SZC) Reduced Dose Level11Feb 2030 est.NCT03813407

Phase 224 drugs

AstraZeneca phase 2 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
AZD2265FPI-226541Dec 2026 est.NCT06909825 · NCT06402331 · NCT05219500
AZD414432Oct 2026 est.NCT07215702 · NCT07783308 · NCT07685600
ALXN20302Oct 2027 est.NCT06744647 · NCT05501717
AZD029222Dec 2027 est.NCT07774403 · NCT07088926
AZD77982NCT06681324 · NCT06450197
Oleclumab2NCT06606847 · NCT03381274
Acalabrutinib + R-CHOP standard of care11Dec 2027 est.NCT07029737
ALXN192011Jul 2027 est.NCT07157787
Anifrolumab + APFS1Sept 2030 est.NCT07630714
AZD01711NCT04999969
AZD116311Nov 2027 est.NCT07276581
AZD2373-Arm 111Aug 2027 est.NCT06824987
AZD238911Jul 2027 est.NCT07610837
AZD514811Apr 2027 est.NCT07285213
AZD679311Nov 2027 est.NCT07082738

Phase 157 drugs

AstraZeneca phase 1 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
AZD13902Apr 2028 est.NCT07643870 · NCT03423628
AZD347022Dec 2028 est.NCT06137144 · NCT06130553
AZD549222May 2027 est.NCT06916806 · NCT06542250
AZD776022Apr 2027 est.NCT07612813 · NCT06749457
[14C]AZD4954 Oral Solution1Dec 2026 est.NCT07812077
Administration of ceralasertib1NCT02264678
ALXN223011Dec 2026 est.NCT07352423
ALXN235011Jan 2032 est.NCT07218887
Anifrolumab: SC formulation via AI1Apr 2029 est.NCT07688980
AZD0120 - Regimen 111Dec 2028 est.NCT07224373

Phase 413 drugs

AstraZeneca phase 4 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Trastuzumab deruxtecan175Oct 2026 est.NCT06429761 · NCT06989112 · NCT06467357
OlaparibAZD228110Apr 2027 est.NCT05457257 · NCT05171816 · NCT04884360
Ravulizumab96Jun 2027 est.NCT07308574 · NCT07221838 · NCT07596784
AnifrolumabMedi-54683Nov 2026 est.NCT06594068 · NCT07751848 · NCT07691970
Acalabrutinib73Jul 2027 est.NCT06651970 · NCT05057494 · NCT04075292
Benralizumab62Oct 2026 est.NCT03953300 · NCT07444567 · NCT06512883
Acoramidis11Mar 2028 est.NCT07306949
Albuterol and budesonide inhalation aerosol1Feb 2027 est.NCT06422689

Derived from 444 active trials AstraZeneca leads; 420 name an intervention, folding into 153 phased drugs. 21 interventions carry no registry phase (observational studies, tests and devices) and are not shown. 1 trial names a placebo or non-interventional arm and is excluded. This is ComplyRx's reading of the registry, not AstraZeneca's own pipeline disclosure.

AstraZeneca trials

The 50 most significant of AstraZeneca's recently active trials, soonest estimated readout first.
Select any row for the full record; the change timeline unlocks with tracking.

TrialPhaseStabilityStatusEnrollmentEst. readout
PRECIOUS EgyptPrevalence, Clinical Characteristics, Progression, and Management of Neurofibromatosis Type 1 in Egypt (NF1-Egy)NCT07221331Not yet scoredOngoingRecruiting200 est.30 Sept 2026
STRIDEPhase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian PatientsNCT06429761Trastuzumab deruxtecanPhase 4Locked · track to revealOngoingActive, not recruiting100 est.31 Oct 2026
OverTTuReOverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR AmyloidosisNCT06355934Not yet scoredOngoingRecruiting52,121 est.2 Nov 2026
A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic ImpairmentNCT07343960CapivasertibPhase 1Locked · track to revealOngoingRecruiting20 est.11 Nov 2026
A Study to Investigate the Relative Bioavailability and Safety of Different Oral Formulations of Elecoglipron in Healthy ParticipantsNCT07723833Elecoglipron Reference Formulation Dose APhase 1Not yet scoredOngoingRecruiting152 est.18 Nov 2026
Study of the Effect of Haemodialysis on the Pharmacokinetics, Safety, and Tolerability of Balcinrenone/DapagliflozinNCT07754331Balcinrenone/dapagliflozinPhase 1Locked · track to revealOngoingRecruiting10 est.3 Dec 2026
A Study Designed to Assess the Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD4954 and the Absolute Bioavailability of AZD4954NCT07812077[14C]AZD4954 Oral SolutionPhase 1Not yet scoredOngoingNot yet recruiting16 est.17 Dec 2026
RIVERSTReatment Approaches and bIomarkers preValence in bladdEr Cancer in RuSsian FederationNCT07038928Not yet scoredOngoingRecruiting600 est.31 Dec 2026
DAISYDetermine Effectiveness of Anifrolumab In SYstemic Sclerosis (DAISY)NCT05925803Anifrolumab (blinded)Phase 3Locked · track to revealOngoingActive, not recruiting314 est.6 Jan 2027
ESSENCEA Study to Investigate Changes in Symptoms in Adult Participants With Chronic Rhinosinusitis With Nasal Polyposis Initiating Treatment With TezepelumabNCT06706817TezepelumabPhase 3Locked · track to revealOngoingActive, not recruiting181 est.13 Jan 2027
LUSIPLung Cancer Screening Implementation Project in the Brazilian Public Health Care System (LUSIP)NCT07279948Not yet scoredOngoingNot yet recruiting477 est.31 Jan 2027
PROceedReal-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)NCT06380738Not yet scoredOngoingActive, not recruiting111 est.14 Feb 2027
Multicenter, Observational, Descriptive Study of the Diagnosis, Course and Treatment of Patients With SLE in Routine Practice in Kazakhstan: a Registry Study With Retrospective and Prospective Components.NCT06899633Not yet scoredOngoingActive, not recruiting509 est.28 Feb 2027
SynagisStudy of Palivizumab in Children With High Risk of Severe Respiratory Syncytial Virus (RSV) DiseaseNCT06851806Palivizumab 15 mg/kgNaLocked · track to revealOngoingActive, not recruiting21 est.28 Feb 2027
EPICObservational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United KingdomNCT05557695AcalabrutinibNot yet scoredOngoingRecruiting287 est.1 Apr 2027
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.NCT07511205AZD1043Phase 1Locked · track to revealOngoingRecruiting104 est.9 Apr 2027
BalanceD-HFStudy to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney FunctionNCT06307652balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mgPhase 3Locked · track to revealOngoingRecruiting3,850 est.16 Apr 2027
PRISMPrevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal AntibodyNCT07285213AZD5148Phase 2Locked · track to revealOngoingRecruiting230 est.20 Apr 2027
TITANA Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.NCT06916806AZD5492Phase 1Locked · track to revealOngoingRecruiting72 est.5 May 2027
PIONEER-PKDSafety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney DiseaseNCT07228364AZD1613 - Part APhase 1Locked · track to revealOngoingRecruiting40 est.22 May 2027
SOLAExplore the Diagnostic Value of Bronchodilation Test With Portable Oscillometry in Asthma DiagnosisNCT07516184Pulmonary function Test interventionNaLocked · track to revealOngoingRecruiting500 est.11 Jun 2027
TROP2 NMR Concordance StudyNCT07624318Reference solutionLocked · track to revealOngoingRecruiting3,400 est.15 Jun 2027
IRENAn Observational Study of Molecular profIling of Advanced and aggRessive ENdometrial Cancer and 1-st Line Treatment Approaches in Russian FederationNCT07041606Not yet scoredOngoingRecruiting500 est.30 Jun 2027
A Translational Study for Phenotyping and Endotyping Chinese Patients With NCFBENCT07245407Participant Follow-upNot yet scoredOngoingActive, not recruiting251 est.29 Jul 2027
A Phase III Study to Assess the Effect of FDC Laroprovstat/Rosuvastatin Compared With Laroprovstat, Rosuvastatin and Placebo on LDL-C in LLT-naïve Patients.NCT07619131LaroprovstatPhase 3Locked · track to revealOngoingRecruiting600 est.30 Jul 2027
Breztri rPMSBREZTRI REGULATORY POST MARKETING SURVEILLANCE IN KOREANCT07570394Not yet scoredOngoingNot yet recruiting600 est.31 Jul 2027
Efficacy and Safety of Ravulizumab in Chinese Adults Participants With Generalized Myasthenia Gravis (gMG)NCT07596784RavulizumabPhase 3Locked · track to revealOngoingRecruiting20 est.17 Aug 2027
PRIMULA LacProspective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab UsersNCT06594068AnifrolumabPhase 4Locked · track to revealOngoingRecruiting16 est.31 Aug 2027
Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese AdultsNCT07646600Observational, None interventionLocked · track to revealOngoingRecruiting10 est.31 Aug 2027
ANASTASIAObservational Study That Will Analyse the Spread and Stratification of Lung Cancer Risk Using Artificial IntelligenceNCT07617636Not yet scoredOngoingNot yet recruiting1,500 est.31 Aug 2027
A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid MalignanciesNCT05123482AZD8205Phase 1Locked · track to revealOngoingRecruiting460 est.29 Sept 2027
iCHOROSStudy of Clinical and Patient-reported Outcomes in Adults With Moderate to Severe COPD Treated With Breztri/TrixeoNCT07069829Not yet scoredOngoingRecruiting1,400 est.30 Sept 2027
SCOPeStudy That Will Evaluate the Brazilian Population With COPD.NCT06780046Not yet scoredOngoingRecruiting693 est.30 Sept 2027
OSTARAA Study to Investigate Safety and Efficacy of Osimertinib and Amivantamab in Participants With Non-small Cell Lung Cancer With Common Epidermal Growth Factor Receptor MutationsNCT05801029OsimertinibPhase 2Locked · track to revealOngoingActive, not recruiting60 est.1 Oct 2027
BAIYUNA Study to Investigate Efficacy and Safety of PT027 Compared With PT007 in Symptomatic Chinese Adults With AsthmaNCT06471257Budesonide/Albuterol metered dose inhaler, MDIPhase 3Locked · track to revealOngoingRecruiting1,000 est.4 Oct 2027
EXPLOREReal-world Study of Trastuzumab Deruxtecan in Patients With Unresectable or Metastatic HER2-low Breast CancerNCT06727227trastuzumab deruxtecanLocked · track to revealOngoingRecruiting138 est.31 Oct 2027
PRESTOA Study to Investigate the Effect of AZD6793 in Participants With Moderate to Very Severe Chronic Obstructive Pulmonary DiseaseNCT07082738AZD6793Phase 2Locked · track to revealOngoingRecruiting987 est.5 Nov 2027
CRIUS-1First-in-Human Study to Evaluate AZD8359 STEAP2 TCE in Participants With Prostate CancerNCT07529717AZD8359Phase 1Locked · track to revealOngoingRecruiting42 est.17 Nov 2027
PULSEA Study of AZD4063 in PLN R14del Dilated CardiomyopathyNCT07241104AZD4063Phase 1Locked · track to revealOngoingRecruiting23 est.22 Nov 2027
CHARM Hepatocellular Carcinoma MEA StudyNCT07650773Locked · track to revealOngoingRecruiting4,000 est.30 Nov 2027
CLEARA Study to Evaluate the Efficacy, Safety, and PK of AZD0292 Administered IV in Participants 12 Years of Age and Older With Bronchiectasis and Chronic Pseudomonas Aeruginosa ColonizationNCT07088926AZD0292Phase 2Locked · track to revealOngoingRecruiting435 est.9 Dec 2027
Pangeia-2Minimally Interventional Study on Prevalence of Emerging ESR1 Mutations in Liquid Biopsy in Three Cohorts of Patients With Breast Cancer in Comparison With Patient's Baseline ESR1 Mutation Status as Defined by Tissue Profiling.NCT06417801Not yet scoredOngoingRecruiting170 est.30 Dec 2027
BIFANGA Study to Investigate NPS and Symptoms in Chinese Adult Participants With CRSwNP Initiating Treatment With TezepelumabNCT07520162TezepelumabPhase 3Locked · track to revealOngoingRecruiting230 est.1 Mar 2028
ARESReAl-woRld Evaluation of tEzepelumab for Chronic rhinoSinusitis With Nasal Polyps in RussiaNCT07399665Locked · track to revealOngoingRecruiting110 est.31 Mar 2028
SOUNDTRACK-BSurovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHLNCT06526793SurovatamigPhase 2Locked · track to revealOngoingRecruiting270 est.21 Apr 2028
CLEAR-AbKDA Study to Assess the Effect of Surovatamig in Adult Participants With Antibody-mediated Kidney DiseaseNCT07571746SurovatamigPhase 2Locked · track to revealOngoingRecruiting43 est.24 Apr 2028
Eluminate-2A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusNCT07662213ElecoglipronPhase 3Locked · track to revealOngoingRecruiting1,200 est.23 May 2028
HORIZONA Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe AsthmaNCT06023589TezepelumabPhase 3Locked · track to revealOngoingRecruiting231 est.31 May 2028
EmboldA Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DMNCT07667803ElecoglipronPhase 3Not yet scoredOngoingRecruiting4,500 est.31 Jul 2028
SELENE 3A Study to Evaluate Effect of AZD6234 as an Adjunct to Incretin-based Therapies in Adult Participants With Obesity or Overweight With Weight-related Comorbidity With or Without Type 2 Diabetes MellitusNCT07776509AZD6234Phase 3Locked · track to revealOngoingRecruiting500 est.9 Aug 2028
View all trials4,054

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We check every one of its trials daily and tell you what moved.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
US registryClinicalTrials.gov
EU registryCTIS · Soon
4,054

Trials as lead sponsor

263

Recruiting now

905

Phase 3 trials

748

Phase 2 trials

1,255

Phase 1 trials

215

Phase 4 trials