Big pharma · PFE · 3,957 trials led

Pfizer clinical trial pipeline

3,957 trials as lead sponsor, 118 recruiting now, 833 in phase 3. Live from ClinicalTrials.gov, updated daily.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
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Archive historyOct 2022 to Sept 2026

158 recorded changes across Pfizer trials

Every status move, completion date shift and enrollment change ComplyRx has recorded across 35 of these trials. One is shown below.

Status changeStatus moved to active not recruiting from recruitingNCT06215118 · recorded 15 Sept 2026
Track to read them

+154 more recorded changes · Track a drug to see every change the night it lands

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Most active programmes

The drugs appearing most often across Pfizer's recently active trials. Comparator arms are excluded.

  • PF-07220060 + PF-07104091 combination dose escalation8 trials
  • Rimegepant5 trials
  • Berobenatide4 trials
  • Elranatamab4 trials
  • PG44 trials
  • 20-valent pneumococcal conjugate vaccine (20vPnC)4 trials

Upcoming readouts

Next primary completion dates among Pfizer's active phase 2 and phase 3 trials. Dates are registry estimates and move often, which is exactly what the tracker watches.

Top therapeutic areas

Conditions studied most often across Pfizer's recently active trials.

  • Obesity8 trials
  • Atopic Dermatitis6 trials
  • Alopecia Areata5 trials
  • Pneumococcal Disease5 trials
  • Overweight5 trials
  • Breast Cancer5 trials

Pfizer pipeline by phase

The main study drugs across 195 active trials Pfizer leads on ClinicalTrials.gov. Each drug sits in the highest phase among its currently active trials, which can be lower than a phase it has already completed.

Phase 345 drugs

Pfizer phase 3 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
PF-086344041110Oct 2027 est.NCT07578649 · NCT07222800 · NCT07222566
vepdegestrantARV-47181Dec 2026 est.NCT05909397 · NCT05654623 · NCT07231991
MET097PF-0865394462Jan 2027 est.NCT07595549 · NCT07400653 · NCT07311850
Disitamab vedotin51Dec 2026 est.NCT05911295 · NCT06157892 · NCT06003231
RSVpreF53Jan 2027 est.NCT07819097 · NCT07653100 · NCT07543380
Etrasimod43Jun 2029 est.NCT03950232 · NCT07470879 · NCT05287126
PG443May 2027 est.NCT07660198 · NCT07629440 · NCT07573462
Ritlecitinib4Dec 2026 est.NCT06163326 · NCT06072183 · NCT07228390
Berobenatide3Mar 2028 est.NCT07794774 · NCT07794761 · NCT07792954
Encorafenib3Oct 2026 est.NCT04657991 · NCT04607421 · NCT05217446
marstacimabPF-0674108633May 2027 est.NCT05611801 · NCT05145127 · NCT06703606
MevrometostatPF-0682149732Dec 2026 est.NCT07028853 · NCT06629779 · NCT06551324
Sigvotatug Vedotin32Jun 2027 est.NCT06758401 · NCT06012435 · NCT04389632
Tilrekimig31Mar 2028 est.NCT07783425 · NCT07772921 · NCT07765888
20vPnC21May 2027 est.NCT07754539 · NCT07023081
Abrocitinib22May 2027 est.NCT06807281 · NCT06807268
ibuzatrelvir22Sept 2027 est.NCT07013474 · NCT06679140
PF-072200602Sept 2026 est.NCT06760637 · NCT04557449
PF-0724814422Jul 2027 est.NCT07062965 · NCT04606446
PF-0804605422Jan 2028 est.NCT07144280 · NCT05208762
Ritlecitinib 100 mg22Mar 2028 est.NCT07733765 · NCT06873945
Ritlecitinib higher dose21Dec 2026 est.NCT07029828 · NCT07029711
VLA1521Dec 2026 est.NCT07500506 · NCT07226882
Avelumab1Dec 2026 est.NCT05059522
Brentuximab vedotin1NCT04404283
C.difficile vaccine11Dec 2028 est.NCT07282665
Dazukibart11Jul 2031 est.NCT06698796
Enzalutamide1NCT02319837
Multivalent Group B streptococcus vaccine11Nov 2028 est.NCT07160244
nirmatrelvir11NCT05261139
PF-068015911NCT04165317
PF-0682385911Jul 2030 est.NCT05895786
PF-06838435/ fidanacogene elaparvovec1NCT03861273
PF-069399261NCT04281485
PF-07055480 (giroctocogene fitelparovec): Recombinant AAV2/6 Human Factor VIII Gene Therapy1NCT04370054
PG4 Multivalent Vaccine1Jun 2027 est.NCT07794748
Rimegepant (PF-07899801)11Jul 2030 est.NCT04743141
Rimegepant/BHV300011Jan 2029 est.NCT04649242
RSVpreF Vaccine11Feb 2028 est.NCT07768345
talazoparib plus enzalutamide1NCT04821622
Talazoparib with enzalutamide1NCT03395197
taldefgrobep alfa1NCT05337553
Testing of hepatic AAV Vector integration11Feb 2040 est.NCT05568719
tofacitinib1Mar 2027 est.NCT04624230
troriluzole1NCT03701399

Phase 217 drugs

Pfizer phase 2 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Palbociclib3Dec 2026 est.NCT05226871 · NCT03709680 · NCT06495164
PF-0727531533Oct 2026 est.NCT07363694 · NCT06977581 · NCT05995964
Osivelotor21Feb 2027 est.NCT05431088 · NCT06507904
PF-0804982022Feb 2028 est.NCT07216027 · NCT07597928
PF-0865394521Jan 2027 est.NCT07575932 · NCT07725809
ponsegromab21Jan 2028 est.NCT06989437 · NCT07663630
ATM-AVI11Mar 2027 est.NCT05639647
Elranatamab (PF-06863135)1NCT04649359
Inotuzumab ozogamicin11May 2033 est.NCT05748171
Low Dose PF-0732894811Nov 2027 est.NCT06991257
Part A: ATM-AVI Single Dose, Cohorts 1-411Apr 2027 est.NCT06462235
PF-0683537511Aug 2028 est.NCT05070845
PF-07104091 monotherapy dose escalation1Dec 2026 est.NCT04553133
PF-07220060 CDK4 inhibitor1NCT06105632
PF-078684891Aug 2028 est.NCT07073820

Phase 130 drugs

Pfizer phase 1 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
PF-0732894822Feb 2027 est.NCT07315360 · NCT07269301
Atirmociclib11Aug 2027 est.NCT07677358
C. difficile vaccine formulation 1.1Jun 2031 est.NCT05805826
E coli vaccine 1 Dose A11May 2028 est.NCT07122986
Mervometostat (PF-06821497)11Apr 2028 est.NCT03460977
MET233 and MET09711NCT06924320
Oral [14C] PF-077995441NCT07578636
PF-07220060 + PF-07104091 combination dose escalation1Feb 2027 est.NCT05262400
PF-077995441Aug 2027 est.NCT05538130
PF-077999331Aug 2027 est.NCT05355701

Phase 49 drugs

Pfizer phase 4 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Tucatinib81Dec 2026 est.NCT07768358 · NCT05253651 · NCT05132582
Elranatamab74Aug 2027 est.NCT06057402 · NCT06152575 · NCT05623020
Rimegepant53Nov 2026 est.NCT07609914 · NCT07729462 · NCT06641466
Lorlatinib31Dec 2026 est.NCT05144997 · NCT03052608 · NCT06487078
Tisotumab Vedotin21Dec 2028 est.NCT06952660 · NCT03485209
Binimetinib only treatment11Jul 2029 est.NCT05203172
Cardiac Imaging1Apr 2029 est.NCT05295290
crizotinib1Mar 2028 est.NCT05160922

Derived from 195 active trials Pfizer leads; 194 name an intervention, folding into 101 phased drugs. 3 interventions carry no registry phase (observational studies, tests and devices) and are not shown. 1 trial names a placebo or non-interventional arm and is excluded. This is ComplyRx's reading of the registry, not Pfizer's own pipeline disclosure.

Pfizer trials

The 50 most significant of Pfizer's recently active trials, soonest estimated readout first.
Select any row for the full record; the change timeline unlocks with tracking.

TrialPhaseStabilityStatusEnrollmentEst. readout
A Study to Learn How Effective is PCV20 to Help Stop Adults Who Have a Higher Chance of Getting PneumoniaNCT07251465Receipt of PCV20Not yet scoredOngoingActive, not recruiting846,279 est.30 Sept 2026
A Retrospective Observational Study of Epidemiology and Outcomes in Transthyretin Amyloid Cardiomyopathy in GermanyNCT07494656tafamidis 61mg (based on prescription data)Locked · track to revealOngoingActive, not recruiting1 est.30 Sept 2026
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic MelanomaNCT04657991EncorafenibPhase 3Locked · track to revealOngoingActive, not recruiting257 est.30 Oct 2026
A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.NCT06629779PF-06821497Phase 3Locked · track to revealOngoingRecruiting900 est.2 Dec 2026
B7981027A Study to Learn About Medicine Called Ritlecitinib in Children Aged Between 6 to 12 Years With Severe Alopecia AreataNCT07029711Ritlecitinib higher dosePhase 3Locked · track to revealOngoingActive, not recruiting208 est.2 Dec 2026
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.NCT07228390RitlecitinibPhase 2Locked · track to revealOngoingActive, not recruiting128 est.8 Dec 2026
Lorlatinib Continuation StudyNCT05144997LorlatinibPhase 4Locked · track to revealOngoingActive, not recruiting76 est.28 Dec 2026
A Study to Learn How the Study Medicine Called PF-08653945 is Taken up Into the Blood in Adults With Overweight or ObesityNCT07725809PF-08653945Phase 1Locked · track to revealOngoingRecruiting57 est.13 Jan 2027
A Study to Learn About the Single Dose Pharmacokinetics of Study Medicine Called Tilrekimig in Healthy Adults When Co-Mixed With rHuPH20NCT07792941tilrekimig and rHuPH20Phase 1Locked · track to revealOngoingRecruiting12 est.11 Feb 2027
A Study to Learn How Different Preparations of Osivelotor Taste and Enter the Blood With Food or Liquids or With an Antacid in Healthy AdultsNCT06507904OsivelotorPhase 1Locked · track to revealOngoingNot yet recruiting52 est.19 Feb 2027
A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid TumorsNCT05262400PF-07220060 + PF-07104091 combination dose escalationPhase 1Locked · track to revealOngoingActive, not recruiting235 est.26 Feb 2027
TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A)NCT05548127ARV-471Phase 1Locked · track to revealOngoingActive, not recruiting37 est.24 Mar 2027
A Study to Learn How Different Amounts of the Study Medicine Called PF-08103402 Are Tolerated and Act in the Body in Healthy Adults or Adults With Mild To-moderate AsthmaNCT07660731PF-08103402Phase 1Not yet scoredOngoingRecruiting133 est.30 Mar 2027
Tranquillo LTEA 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental VitiligoNCT06163326RitlecitinibPhase 3Locked · track to revealOngoingActive, not recruiting394 est.31 Mar 2027
Real-World Effectiveness of Ritlecitinib in Alopecia Areata Patients in the US: A Retrospective Analysis Using EHR and Claims DataNCT07821216ritlecitinibNot yet scoredOngoingNot yet recruiting7,500 est.20 Apr 2027
A Study to Learn About How a New Pneumococcal Vaccine Works in InfantsNCT06524414PG4Phase 2Locked · track to revealOngoingActive, not recruiting605 est.1 May 2027
A Study of the Medicine Called Abrocitinib in Children 6 to Less Than 12 Years of Age With Moderate-to-Severe EczemaNCT06807268AbrocitinibPhase 3Locked · track to revealOngoingRecruiting150 est.2 May 2027
EFFECT-UCA Study to Learn About the Effectiveness of Etrasimod in People With Ulcerative ColitisNCT06294925EtrasimodNot yet scoredOngoingActive, not recruiting360 est.13 May 2027
A Study to Learn About the Safety and Immune Responses of RSVpreF in Older AdultsNCT07819097RSVpreFPhase 3Not yet scoredOngoingNot yet recruiting600 est.15 May 2027
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to AdultsNCT07794748PG4 Multivalent VaccinePhase 3Not yet scoredOngoingNot yet recruiting4,670 est.7 Jun 2027
A Safety Study of SEA-CD70 in Patients With Myeloid MalignanciesNCT04227847SEA-CD70Phase 1Locked · track to revealOngoingActive, not recruiting170 est.4 Jul 2027
SOLIS-1A Study of PF-08653945 and PF-08653944 in Adults With Overweight or ObesityNCT07575932PF-08653945Phase 2Locked · track to revealOngoingActive, not recruiting940 est.4 Aug 2027
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.NCT05355701PF-07799933Phase 1Locked · track to revealOngoingActive, not recruiting103 est.31 Aug 2027
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid TumorsNCT05538130PF-07799544Phase 1Locked · track to revealOngoingActive, not recruiting148 est.31 Aug 2027
A Study to Learn How Different Amounts of the Study Medicine Called PF-08065010 Are Tolerated and Act in the Body of Healthy AdultsNCT07235163PF-08065010Phase 1Locked · track to revealOngoingRecruiting100 est.1 Sept 2027
VESPER-4Efficacy and Safety of MET097 Once-Weekly in People With Overweight or ObesityNCT07311850MET097Phase 3Locked · track to revealOngoingActive, not recruiting3,578 est.21 Sept 2027
A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely ImmunocompromisedNCT07013474ibuzatrelvirPhase 3Locked · track to revealOngoingRecruiting300 est.27 Sept 2027
A Study to Learn About the Study Medicine (PF-08653944) in People With Obesity or Overweight and Type 2 Diabetes (T2D)NCT07400653PF-08653944Phase 3Locked · track to revealOngoingActive, not recruiting1,078 est.12 Oct 2027
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast CancerNCT06966453Disitamab vedotinPhase 1Locked · track to revealOngoingActive, not recruiting74 est.25 Oct 2027
A Study to Learn About the Effects of the Combination of Elranatamab (PF-06863135) and Iberdomide in Patients With Relapsed or Refractory Multiple Myeloma (MagnetisMM-30)NCT06215118ElranatamabPhase 1Locked · track to revealOngoingActive, not recruiting100 est.16 Nov 2027
Study to Learn About Safety, Tolerability, and Immune Response of a Catch-up Pneumococcal Vaccine in Children and AdolescentsNCT07660198PG4Phase 3Not yet scoredOngoingRecruiting1,200 est.2 Dec 2027
A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in IndiaNCT07685769Rimegepant 75 mg ODTPhase 4Not yet scoredOngoingRecruiting60 est.4 Jan 2028
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and FatigueNCT06989437ponsegromabPhase 2Locked · track to revealOngoingRecruiting982 est.17 Jan 2028
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocompromised AdultsNCT07768345RSVpreF VaccinePhase 3Locked · track to revealOngoingRecruiting440 est.2 Feb 2028
A Study to Learn About Study Medicine Called PF-08049820 in People With EczemaNCT07216027PF-08049820Phase 2Locked · track to revealOngoingRecruiting165 est.2 Feb 2028
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)NCT07144280PF-08046054Phase 3Locked · track to revealOngoingRecruiting680 est.10 Mar 2028
A Study to Learn About the Study Medicine Called Tilrekimig in People With Moderate-to-Severe EczemaNCT07765888TilrekimigPhase 3Locked · track to revealOngoingRecruiting375 est.10 Mar 2028
A Study to Learn About the Study Medicine Called PF-08653944 Taken Once-Weekly Compared to Placebo in Chinese Adults With Overweight or ObesityNCT07792954BerobenatidePhase 3Not yet scoredOngoingNot yet recruiting300 est.14 Mar 2028
ALLEGRO-100A Study of 2 Doses of Ritlecitinib in People 12 Years of Age and Older With Alopecia AreataNCT06873945Ritlecitinib 100 mgPhase 3Locked · track to revealOngoingRecruiting1,330 est.19 Mar 2028
PRESTOCharacterization And Clinical Outcomes of AA Patients Treated With RitlecitinibNCT06531109RitlecitinibNot yet scoredOngoingActive, not recruiting450 est.15 Apr 2028
Study of Pregnancy Outcomes in Women Exposed to Rimegepant During PregnancyNCT05198245RimegepantNot yet scoredOngoingActive, not recruiting1 est.17 Apr 2028
A Study of Mevrometostat for Treatment of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular LymphomaNCT03460977Mervometostat (PF-06821497)Phase 1Locked · track to revealOngoingRecruiting453 est.20 Apr 2028
A Study in Young People and Adults to Learn About the Medicine Ritlecitinib for Treatment of Patchy Hair Loss, Known by the Medical Term as Moderate Alopecia AreataNCT07733765Ritlecitinib 100 mgPhase 3Not yet scoredOngoingRecruiting336 est.26 Apr 2028
ATTR-CM: A Multi-country, Non-interventional Disease RegistryNCT06651073ObservationalNot yet scoredOngoingActive, not recruiting350 est.28 Apr 2028
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or ObesityNCT07595549PF-08653944Phase 3Locked · track to revealOngoingRecruiting954 est.4 May 2028
A Study to Learn About the Study Medicine Called Ponsegromab in Adults With Lung Cancer-Associated Significant Body Weight LossNCT07663630ponsegromabPhase 1Locked · track to revealOngoingNot yet recruiting80 est.5 May 2028
A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With MigraineNCT07609914RimegepantPhase 4Locked · track to revealOngoingRecruiting400 est.15 May 2028
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Use a Breathing Machine (PAP) (VESPER-OSA 1)NCT07823608BerobenatidePhase 3Not yet scoredOngoingNot yet recruiting258 est.19 Jun 2028
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid TumorsNCT07090499PF-08046876Phase 1Locked · track to revealOngoingRecruiting540 est.8 Jul 2028
Phase 1 Study of PF-08046033 in Advanced Solid TumorsNCT07519655PF-08046033Phase 1Locked · track to revealOngoingRecruiting250 est.14 Jul 2028
View all trials3,957

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We check every one of its trials daily and tell you what moved.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
US registryClinicalTrials.gov
EU registryCTIS · Soon
3,957

Trials as lead sponsor

118

Recruiting now

833

Phase 3 trials

810

Phase 2 trials

1,407

Phase 1 trials

294

Phase 4 trials