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Immuno-oncology checkpoint inhibitors · Live ClinicalTrials.gov data

Pembrolizumab (Keytruda) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 pembrolizumab (Keytruda) trials on ClinicalTrials.gov by enrolment, 5 of them actively recruiting. The next phase 3 primary completion among them is expected Jan 2028. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

7

Phase 3 trials

5

Actively recruiting

Jan 2028

Next phase 3 primary completion

7,557

Participants across trials

Merck Sharp & Dohme LLC

Lead sponsor by trial count

pembrolizumab (16)13 active2016–2032
pembrolizumab
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompletedTerminatedUnknown status
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pembrolizumab
A Study of Pembrolizumab With Carboplatin and Gemcitabine in Patients With Metastatic Triple Negative Breast CancerP2
Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)P3
Safety and Efficacy of Capmatinib (INC280) Plus Pembrolizumab vs Pembrolizumab Alone in NSCLC With PD-L1≥ 50%P2
Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as First-line Intervention in Adults With Advanced Melanoma (MK-7902-003/E7080-G000-312/LEAP-003)-China Extension StudyP3
MITO 27P2
Pembrolizumab in Post Radical Operation ESCC Patients With Lymph Node Positive ( KEYSTONE-004 )P2
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)P3
KEYNOTE-C11P2
Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for Treatment of Recurrent (Non-small Cell) Lung CancerP2
DIALP2
TroFuse-007P3
STELLAR-305P2
Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial CarcinomaP2
Krascendo 2P3
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung CancerP3
Chrono-EVPP3

Upcoming readouts

6 ahead · pembrolizumab

Select a trial to load its full ClinicalTrials.gov record.

Key pembrolizumab trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT06170788TroFuse-007: Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone i…Phase 3RecruitingJan 2028
NCT06793215Krascendo 2: A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab a…Phase 3RecruitingNov 2028
NCT07222566Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination …Phase 3RecruitingFeb 2029
NCT04895358Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2…Phase 3Active, not recruitingApr 2026
NCT07346053Chrono-EVP: The Impact of Time-of-day Administration of EV/P on Objective Response Rate in Adults With Advan…Phase 3Not yet recruitingDec 2030
NCT03834506Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-na…Phase 3CompletedJun 2022
NCT04889118Safety and Efficacy Study of Pembrolizumab (MK-3475) Combined With Lenvatinib (MK-7902/E7080) as…Phase 3CompletedJan 2023
NCT05255302DIAL: De-escalation Immunotherapy mAintenance Duration Trial for Stage IV Lung Cancer Patients With Di…Phase 2RecruitingMay 2025
NCT07129993Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplati…Phase 2RecruitingJun 2029
NCT05117242Safety and Efficacy Study of GEN1046 as a Single Agent or in Combination With Pembrolizumab for …Phase 2Active, not recruitingDec 2024
NCT02755272A Study of Pembrolizumab With Carboplatin and Gemcitabine in Patients With Metastatic Triple Neg…Phase 2Active, not recruitingMay 2026
NCT06082167STELLAR-305: Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive …Phase 2Active, not recruitingAug 2028

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FAQ

How many clinical trials are running for pembrolizumab?
ClinicalTrials.gov lists more than 16 phase 2–4 pembrolizumab trials. This page tracks the 16 largest by enrolment: 9 phase 2, 7 phase 3, and 0 phase 4 among them, with 5 actively recruiting. Updated daily.
Are there clinical trials for Keytruda?
Keytruda is the brand name for pembrolizumab, so pembrolizumab trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 pembrolizumab trials. This page tracks the 16 largest by enrolment: 9 phase 2, 7 phase 3, and 0 phase 4 among them, with 5 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare pembrolizumab against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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