16+
Major trials tracked
Immuno-oncology checkpoint inhibitors · Live ClinicalTrials.gov data
Nivolumab (Opdivo) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 nivolumab trials on ClinicalTrials.gov by enrolment, 6 of them actively recruiting. The next phase 3 primary completion among them is expected Jul 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.
3
Phase 3 trials
6
Actively recruiting
Jul 2027
Next phase 3 primary completion
2,845
Participants across trials
National Cancer Institute (NCI)
Lead sponsor by trial count
nivolumab (16)12 active2017–2032
nivolumab
'17
'19
'21
'23
'25
'27
'29
'31
nivolumab
Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell CarcinomaP2
CheckMate 907P2
Study of Nivolumab in Combination With Gemcitabine/Cisplatin or Ipilimumab for Patients With Advanced Unresectable Biliary Tract CancerP2
UNISoNP2
A Phase II of Nivolumab Plus Ipilimumab in Non-resectable Sarcoma and Endometrial CarcinomaP2
Platinum-doublet Chemotherapy and Nivolumab for the Treatment of Subjects With Neuroendocrine Neoplasms (NENs) of the Gastroenteropancreatic (GEP) Tract or of Unknown (UK) Origin.P2
INSPIREP2
TEDOPAMP2
Study of Adjuvant Chemotherapy With or Without PD-1 Inhibitors and Chemoradiotherapy in Resected pN3 Gastric (G) or GEJ AdenocarcinomaP3
PNACGECP2
A Study to Evaluate the Efficacy and Safety of ONO-4538 in Combination With Ipilimumab and Chemotherapy in Chemotherapy-naïve Participants With HER2-negative Unresectable Advanced or Recurrent Gastric Cancer (Including Esophagogastric Junction Cancer)P3
Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 NegativeP2
SCANDIUM-IIIP3
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE TrialP2
VALUE-CHECKP2
IMCODE004P2
Upcoming readouts
7 ahead · nivolumab
Select a trial to load its full ClinicalTrials.gov record.
Key nivolumab trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT04997837 | Study of Adjuvant Chemotherapy With or Without PD-1 Inhibitors and Chemoradiotherapy in Resected… | Phase 3 | Recruiting | Jul 2027 |
| NCT06519266 | SCANDIUM-III: PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma L… | Phase 3 | Recruiting | Dec 2028 |
| NCT05144854 | A Study to Evaluate the Efficacy and Safety of ONO-4538 in Combination With Ipilimumab and Chemo… | Phase 3 | Active, not recruiting | Oct 2025 |
| NCT05033392 | PNACGEC: PD-1 Blockade With JS001 Plus Neoadjuvant Chemotherapy for Gastric/Gastroesophageal Junction Can… | Phase 2 | Recruiting | Dec 2026 |
| NCT06203600 | Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAM… | Phase 2 | Recruiting | Oct 2027 |
| NCT06534983 | IMCODE004: A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivoluma… | Phase 2 | Recruiting | Nov 2027 |
| NCT06422403 | VALUE-CHECK: A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancer… | Phase 2 | Recruiting | Mar 2029 |
| NCT03071406 | Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma | Phase 2 | Active, not recruiting | Apr 2022 |
| NCT03806309 | TEDOPAM: OSE2101+FOLFIRI, or FOLFIRI Maintenance After FOLFIRINOX-based Induction Therapy in Advanced or … | Phase 2 | Active, not recruiting | Dec 2024 |
| NCT03101566 | Study of Nivolumab in Combination With Gemcitabine/Cisplatin or Ipilimumab for Patients With Adv… | Phase 2 | Completed | Dec 2019 |
| NCT03090737 | CheckMate 907: Safety Study of Nivolumab to Treat Advanced or Metastatic Non-small Cell Lung Cancer | Phase 2 | Completed | Feb 2021 |
| NCT03980925 | Platinum-doublet Chemotherapy and Nivolumab for the Treatment of Subjects With Neuroendocrine Ne… | Phase 2 | Completed | Feb 2023 |
Related drug pipelines
FAQ
- How many clinical trials are running for nivolumab?
- ClinicalTrials.gov lists more than 16 phase 2–4 nivolumab trials. This page tracks the 16 largest by enrolment: 13 phase 2, 3 phase 3, and 0 phase 4 among them, with 6 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare nivolumab against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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