ComplyRx

Targeted & bispecific oncology · Live ClinicalTrials.gov data

Amivantamab (Rybrevant) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 amivantamab (Rybrevant) trials on ClinicalTrials.gov by enrolment, 9 of them actively recruiting. The next phase 3 primary completion among them is expected Dec 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

7

Phase 3 trials

9

Actively recruiting

Dec 2027

Next phase 3 primary completion

7,659

Participants across trials

Janssen Research & Development, LLC

Lead sponsor by trial count

amivantamab (16)16 active2018–2031
amivantamab
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruiting
'18
'20
'22
'24
'26
'28
'30
amivantamab
BoBP2
MARIPOSAP3
PAPILLONP3
MARIPOSA-2P3
PALOMA-3P3
PALOMA-2P2
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)P2
COCOONP2
OrigAMI-2P3
Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)P2
OrigAMI-3P3
COPERNICUSP2
An Open-label, Single-arm, Multicenter Phase II Study to Evaluate the Efficacy of Amivantamab in Combination With FOLFIRI as a Second-line Treatment in Patients With RAS/BRAF Wild-type Advanced Colorectal Cancer Progressing on Prior Anti-EGFR Based Treatment.P2
OrigAMI-5P3
Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune SystemP2
AmiCAREP4

Upcoming readouts

10 ahead · amivantamab

Select a trial to load its full ClinicalTrials.gov record.

Key amivantamab trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT07469488AmiCARE: A Clinical Trial on the Outcomes of Comprehensive Enhanced Prophylaxis Management (CEPM) in Chin…Phase 4Not yet recruitingAug 2029
NCT06750094OrigAMI-3: A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With…Phase 3RecruitingDec 2027
NCT06662786OrigAMI-2: A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First…Phase 3RecruitingDec 2028
NCT07276399OrigAMI-5: A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in P…Phase 3RecruitingJun 2029
NCT04538664PAPILLON: A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin…Phase 3Active, not recruitingMay 2023
NCT04988295MARIPOSA-2: A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared W…Phase 3Active, not recruitingJul 2023
NCT04487080MARIPOSA: A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced…Phase 3Active, not recruitingAug 2023
NCT05388669PALOMA-3: A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Par…Phase 3Active, not recruitingJan 2024
NCT03767075BoB: A Modular Multi-Basket Trial to Improve Personalized Medicine in Cancer Patients (Basket of Bask…Phase 2RecruitingMay 2025
NCT05845450Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)Phase 2RecruitingMay 2026
NCT05498428PALOMA-2: A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epider…Phase 2RecruitingAug 2027
NCT06116682Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET …Phase 2RecruitingMay 2028

Track amivantamab with ComplyRx

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FAQ

How many clinical trials are running for amivantamab?
ClinicalTrials.gov lists more than 16 phase 2–4 amivantamab trials. This page tracks the 16 largest by enrolment: 8 phase 2, 7 phase 3, and 1 phase 4 among them, with 9 actively recruiting. Updated daily.
Are there clinical trials for Rybrevant?
Rybrevant is the brand name for amivantamab, so amivantamab trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 amivantamab trials. This page tracks the 16 largest by enrolment: 8 phase 2, 7 phase 3, and 1 phase 4 among them, with 9 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare amivantamab against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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