Targeted & bispecific oncology · Live ClinicalTrials.gov data

Zanubrutinib (Brukinsa) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 zanubrutinib (Brukinsa) trials on ClinicalTrials.gov by enrolment, 5 of them actively recruiting. The next phase 3 primary completion among them is expected Jul 2028. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

4

Phase 3 trials

5

Actively recruiting

Jul 2028

Next phase 3 primary completion

3,227

Participants across trials

BeOne Medicines

Lead sponsor by trial count

zanubrutinib (16)13 active2017–2034
zanubrutinib
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompletedUnknown status
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'19
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'23
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'27
'29
'31
'33
zanubrutinib
Study to Evaluate Efficacy and Safety of BGB-3111 in Participants With Relapsed or Refractory Mantle Cell Lymphoma (MCL)P2
ALPINEP3
MANGROVEP3
Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) TreatmentP2
ZR-CHOP in DLBCL With Specific Gene AbnormalityP2
Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic LymphomaP2
MAHOGANYP3
ALMONDP2
The Efficacy and Safety of Pola-ZR2 Versus ZR2 in the Treatment of Old Patients With de Novo Diffuse Large B-cell LymphomaP3
Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaP2
Epco, Zanu, Ritux for R/R FL or MZLP2
Zanubrutinib, Obinutuzumab, Sonrotoclax (BOSon) or BGB-16673, Obinutuzumab, Sonrotoclax (DOSon) in TN CLL/SLLP2
Zanubrutinib, Chidamide, and Rituximab Induction With or Without CHOP Versus R-CHOP in Newly Diagnosed Double-Expressor DLBCLP2
LME-Guided Precision Combination Therapy in B-cell Lymphoma Patients After CD19 CAR-T FailureP2
PRAISEP2
ZEN-CLLP2

Upcoming readouts

11 ahead · zanubrutinib

Select a trial to load its full ClinicalTrials.gov record.

Key zanubrutinib trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT06522555The Efficacy and Safety of Pola-ZR2 Versus ZR2 in the Treatment of Old Patients With de Novo Dif…Phase 3RecruitingAug 2028
NCT04002297MANGROVE: A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Pl…Phase 3Active, not recruitingApr 2026
NCT05100862MAHOGANY: A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With R…Phase 3Active, not recruitingJul 2028
NCT03734016ALPINE: A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chr…Phase 3CompletedAug 2022
NCT06849713Zanubrutinib, Obinutuzumab, Sonrotoclax (BOSon) or BGB-16673, Obinutuzumab, Sonrotoclax (DOSon) …Phase 2RecruitingMar 2028
NCT04840602Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrut…Phase 2RecruitingMar 2028
NCT06563596Epco, Zanu, Ritux for R/R FL or MZLPhase 2RecruitingMar 2030
NCT06544785Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small …Phase 2RecruitingMay 2032
NCT05707377ALMOND: A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membrano…Phase 2Active, not recruitingOct 2027
NCT07602322LME-Guided Precision Combination Therapy in B-cell Lymphoma Patients After CD19 CAR-T FailurePhase 2Not yet recruitingMay 2028
NCT07739459ZEN-CLL: Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (…Phase 2Not yet recruitingApr 2029
NCT07717177PRAISE: AI-Driven Treatment Strategy vs ZR2 in Older Treatment-naive Patients With LBCLPhase 2Not yet recruitingJun 2029

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Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

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FAQ

How many clinical trials are running for zanubrutinib?
ClinicalTrials.gov lists more than 16 phase 2–4 zanubrutinib trials. This page tracks the 16 largest by enrolment: 12 phase 2, 4 phase 3, and 0 phase 4 among them, with 5 actively recruiting. Updated daily.
Are there clinical trials for Brukinsa?
Brukinsa is the brand name for zanubrutinib, so zanubrutinib trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 zanubrutinib trials. This page tracks the 16 largest by enrolment: 12 phase 2, 4 phase 3, and 0 phase 4 among them, with 5 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare zanubrutinib against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

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