Targeted & bispecific oncology · Live ClinicalTrials.gov data

Zanubrutinib (Brukinsa) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 zanubrutinib (Brukinsa) trials on ClinicalTrials.gov by enrolment, 7 of them actively recruiting. The next phase 3 primary completion among them is expected Jan 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

3

Phase 3 trials

7

Actively recruiting

Jan 2027

Next phase 3 primary completion

2,578

Participants across trials

BeiGene

Lead sponsor by trial count

zanubrutinib (16)13 active20172034
zanubrutinib
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompletedUnknown status
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'27
'29
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'33
zanubrutinib
ROSEWOODP2
MAGNOLIAP2
Zanubrutinib (BGB-3111) in Participants With Previously Treated B-Cell Lymphoma Intolerant of Prior Bruton Tyrosine Kinase Inhibitor (BTKi) TreatmentP2
Study of Zanubrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-cell Non-Hodgkin LymphomaP3
BRUIN-MCL-321P3
Rituximab,Zanubrutinib in Combination With Lenalidomide, Followed by Zanubrutinib or Lenalidomide Maintenance in Patients With Primary or Secondary CNS LymphomaP2
R-ICE+XP2
Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaP2
Pola-ZR2P in Previously Untreated DLBCLP2
Efficacy and Safety of Pola-RCHP-X vs Pola-RCHP in Untreated DLBCLP2
ZeTAP2
ZR2 Versus R2 Regimen in the Treatment of Newly Diagnosed Follicular LymphomaP2
A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell MalignanciesP2
Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLLP3
GUIDANCE-10P2
ZEN-CLLP2

Upcoming readouts

10 ahead · zanubrutinib

Select a trial to load its full ClinicalTrials.gov record.

Key zanubrutinib trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT07321652Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, fo…Phase 3RecruitingSept 2028
NCT04662255BRUIN-MCL-321: Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell…Phase 3Active, not recruitingJan 2027
NCT05164770Study of Zanubrutinib, Rituximab and Combination Chemotherapy in Newly-diagnosed Aggressive B-ce…Phase 3UnknownDec 2023
NCT05348213R-ICE+X: Novel Targeted Drugs Combined With R-ICE Regimen in Relapsed and Refractory Diffuse Large B-cell…Phase 2RecruitingJun 2025
NCT07271667A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants Wit…Phase 2RecruitingNov 2027
NCT06803693Efficacy and Safety of Pola-RCHP-X vs Pola-RCHP in Untreated DLBCLPhase 2RecruitingApr 2028
NCT06167785ZeTA: A Study to Evaluate Zanubrutinib and Tislelizumab in Progressive Lymphoma Post CAR-TPhase 2RecruitingApr 2029
NCT06664411Pola-ZR2P in Previously Untreated DLBCLPhase 2RecruitingDec 2029
NCT06544785Zanubrutinib With Obinutuzumab in Untreated Patients With Chronic Lymphocytic Leukemia or Small …Phase 2RecruitingMay 2032
NCT07739459ZEN-CLL: Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (…Phase 2Not yet recruitingApr 2029
NCT07594899GUIDANCE-10: AI-Driven Treatment Strategy vs Pola-R-CHP in Untreated LBCLPhase 2Not yet recruitingMay 2029
NCT07505849ZR2 Versus R2 Regimen in the Treatment of Newly Diagnosed Follicular LymphomaPhase 2Not yet recruitingMar 2030

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Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

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FAQ

How many clinical trials are running for zanubrutinib?
ClinicalTrials.gov lists more than 16 phase 2–4 zanubrutinib trials. This page tracks the 16 largest by enrolment: 13 phase 2, 3 phase 3, and 0 phase 4 among them, with 7 actively recruiting. Updated daily.
Are there clinical trials for Brukinsa?
Brukinsa is the brand name for zanubrutinib, so zanubrutinib trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 zanubrutinib trials. This page tracks the 16 largest by enrolment: 13 phase 2, 3 phase 3, and 0 phase 4 among them, with 7 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare zanubrutinib against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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