How many clinical trials are running for upadacitinib?

ClinicalTrials.gov lists more than 16 phase 2–4 upadacitinib trials. This page tracks the 16 largest by enrolment: 1 phase 2, 10 phase 3, and 5 phase 4 among them, with 4 actively recruiting. Updated daily.

Are there clinical trials for Rinvoq?

Rinvoq is the brand name for upadacitinib, so upadacitinib trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 upadacitinib trials. This page tracks the 16 largest by enrolment: 1 phase 2, 10 phase 3, and 5 phase 4 among them, with 4 actively recruiting. Updated daily.

Where does this data come from?

All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.

Can I compare upadacitinib against other drugs?

Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Immunology & inflammation · Live ClinicalTrials.gov data

Upadacitinib (Rinvoq) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 upadacitinib (Rinvoq) trials on ClinicalTrials.gov by enrolment, 4 of them actively recruiting. The next phase 3 primary completion among them is expected Jul 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

Phase 3 trials

Actively recruiting

Jul 2027

Next phase 3 primary completion

12,786

Participants across trials

AbbVie

Lead sponsor by trial count

upadacitinib (16)9 active2015–2032

Hide completed

upadacitinib

Key

Actual date

Anticipated

Forecast to primary completion

RecruitingActive, not recruitingCompletedUnknown status

'15

'17

'19

'21

'23

'25

'27

'29

'31

upadacitinib

SELECT-COMPAREP3

A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)P3

A Study to Evaluate ABT-494 (Upadacitinib) in Adults With Moderate to Severe Atopic DermatitisP2

U-ACTIVATEP3

SELECT - PsA 1P3

SELECT - PsA 2P3

A Study to Evaluate Upadacitinib in Adolescents and Adults With Moderate to Severe Atopic Dermatitis (Measure Up 2)P3

AD UpP3

DOPPLERP3

COVERP4

Flex-UpP4

Step-Up HSP3

Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcerative ColitisP4

Efficacy and Safety of Dual-targeted Therapy With Upadacitinib and Ustekinumab Versus Intensified Ustekinumab Therapy in Crohn's DiseaseP4

Start UpP3

Upadacitinib Versus Infliximab as Second-Line Treatment for Acute Severe Ulcerative Colitis（UPRISE）P4

Upcoming readouts

6 ahead · upadacitinib

Select a trial to load its full ClinicalTrials.gov record.

Key upadacitinib trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

Trial	Title	Phase	Status	Primary completion
NCT06520397	Efficacy and Safety of Dual-targeted Therapy With Upadacitinib and Ustekinumab Versus Intensifie…	Phase 4	Recruiting	Dec 2026
NCT05867329	Feasibility Pilot Sequential Multiple Assignment Randomized Trial (SMART) for Acute Severe Ulcer…	Phase 4	Recruiting	Nov 2027
NCT07550673	Upadacitinib Versus Infliximab as Second-Line Treatment for Acute Severe Ulcerative Colitis（UPRI…	Phase 4	Recruiting	Apr 2028
NCT05080218	COVER: COVID-19 VaccinE Response in Rheumatology Patients	Phase 4	Completed	Apr 2024
NCT05507580	Flex-Up: A Study to Assess Treat-to-Target and Dosing Flexibility of Oral Upadacitinib Tablets in Adult P…	Phase 4	Completed	Jul 2024
NCT06461897	Start Up: A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to S…	Phase 3	Recruiting	Jul 2030
NCT02629159	SELECT-COMPARE: A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid …	Phase 3	Active, not recruiting	Oct 2017
NCT03568318	AD Up: A Study to Evaluate Upadacitinib in Combination With Topical Corticosteroids in Adolescent and A…	Phase 3	Active, not recruiting	Feb 2021
NCT03006068	U-ACTIVATE: A Study to Evaluate the Long-Term Safety and Efficacy of Upadacitinib (ABT-494) in Participants …	Phase 3	Active, not recruiting	Jul 2027
NCT05889182	Step-Up HS: A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult an…	Phase 3	Active, not recruiting	Mar 2028
NCT02706951	A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults…	Phase 3	Completed	Oct 2017
NCT03104374	SELECT - PsA 2: A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthri…	Phase 3	Completed	Jul 2019

Track upadacitinib with ComplyRx

Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

Track upadacitinib

Compare upadacitinib vs dupilumab Compare upadacitinib vs lebrikizumab

FAQ

How many clinical trials are running for upadacitinib?: ClinicalTrials.gov lists more than 16 phase 2–4 upadacitinib trials. This page tracks the 16 largest by enrolment: 1 phase 2, 10 phase 3, and 5 phase 4 among them, with 4 actively recruiting. Updated daily.
Are there clinical trials for Rinvoq?: Rinvoq is the brand name for upadacitinib, so upadacitinib trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 upadacitinib trials. This page tracks the 16 largest by enrolment: 1 phase 2, 10 phase 3, and 5 phase 4 among them, with 4 actively recruiting. Updated daily.
Where does this data come from?: All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare upadacitinib against other drugs?: Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Upcoming readouts

Key upadacitinib trials

Track upadacitinib with ComplyRx

Related drug pipelines

FAQ

Keep followingwhat matters.

Keep following
what matters.