16+
Major trials tracked
Immunology & inflammation · Live ClinicalTrials.gov data
Upadacitinib (Rinvoq) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 upadacitinib trials on ClinicalTrials.gov by enrolment, 4 of them actively recruiting. The next phase 3 primary completion among them is expected Feb 2027. Refreshed daily — add up to four competitors to compare pipelines side by side.
11
Phase 3 trials
4
Actively recruiting
Feb 2027
Next phase 3 primary completion
11,511
Participants across trials
AbbVie
Lead sponsor by trial count
upadacitinib (16)7 active2014–2031
upadacitinib
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upadacitinib
A Study Investigating the Efficacy and Safety of Upadacitinib (ABT-494) Given With Methotrexate (MTX) in Adults With Rheumatoid Arthritis Who Have Had an Inadequate Response to MTX AloneP2
SELECT-COMPAREP3
A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)P3
BIO3P4
A Study to Evaluate the Safety and Efficacy of Upadacitinib (ABT-494) for Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis (UC)P2
Measure Up 1P3
Rising UpP3
U-AccomplishP3
SELECT-AXIS 2P3
Open-Label Extension Study of Upadacitinib in Adult Participants With Moderate to Severe Atopic DermatitisP3
RA-PROPRP3
Flex-UpP4
Step-Up HSP3
SELECT-SLEP3
JAK-TAPP4
VICTRIVAP3
Upcoming readouts
6 ahead · upadacitinib
Select a trial to load its full ClinicalTrials.gov record.
Key upadacitinib trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT02714634 | BIO3 — Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + … | Phase 4 | Recruiting | Mar 2029 |
| NCT06687551 | JAK-TAP — JAK Inhibitor Dose TAPering Strategy Study | Phase 4 | Not yet recruiting | Apr 2029 |
| NCT05507580 | Flex-Up — A Study to Assess Treat-to-Target and Dosing Flexibility of Oral Upadacitinib Tablets in Adult Participants Wi… | Phase 4 | Completed | Jul 2024 |
| NCT04692493 | RA-PROPR — RA-PRO PRAGMATIC TRIAL | Phase 3 | Recruiting | Feb 2027 |
| NCT06227910 | VICTRIVA — A Study of Vedolizumab With and Without Upadacitinib in Adults With Crohn's Disease | Phase 3 | Recruiting | Jun 2027 |
| NCT05889182 | Step-Up HS — A Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib in Adult and Adolescent P… | Phase 3 | Recruiting | Mar 2028 |
| NCT02629159 | SELECT-COMPARE — A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Adults With Rheumatoid Arthritis Who … | Phase 3 | Active, not recruiting | Oct 2017 |
| NCT05843643 | SELECT-SLE — Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants Wit… | Phase 3 | Active, not recruiting | Mar 2027 |
| NCT02706951 | A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumato… | Phase 3 | Completed | Oct 2017 |
| NCT03569293 | Measure Up 1 — Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema) | Phase 3 | Completed | Jan 2021 |
| NCT03653026 | U-Accomplish — A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Activ… | Phase 3 | Completed | Jan 2021 |
| NCT04169373 | SELECT-AXIS 2 — A Study to Evaluate Efficacy and Safety of Upadacitinib in Adults With Axial Spondyloarthritis | Phase 3 | Completed | Sept 2021 |
Related drug pipelines
FAQ
- How many clinical trials are running for upadacitinib?
- ClinicalTrials.gov lists more than 16 phase 2–4 upadacitinib trials. This page tracks the 16 largest by enrolment: 2 phase 2, 11 phase 3, and 3 phase 4 among them, with 4 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare upadacitinib against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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