How many clinical trials are running for guselkumab?

ClinicalTrials.gov lists more than 16 phase 2–4 guselkumab trials. This page tracks the 16 largest by enrolment: 4 phase 2, 10 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.

Are there clinical trials for Tremfya?

Tremfya is the brand name for guselkumab, so guselkumab trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 guselkumab trials. This page tracks the 16 largest by enrolment: 4 phase 2, 10 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.

Where does this data come from?

All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.

Can I compare guselkumab against other drugs?

Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Immunology & inflammation · Live ClinicalTrials.gov data

Guselkumab (Tremfya) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 guselkumab (Tremfya) trials on ClinicalTrials.gov by enrolment, 2 of them actively recruiting. The next phase 3 primary completion among them is expected Feb 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

Phase 3 trials

Actively recruiting

Feb 2027

Next phase 3 primary completion

8,506

Participants across trials

Janssen Research & Development, LLC

Lead sponsor by trial count

guselkumab (16)8 active2014–2030

Hide completed

guselkumab

Key

Actual date

Anticipated

Forecast to primary completion

RecruitingActive, not recruitingCompletedTerminated

'14

'16

'18

'20

'22

'24

'26

'28

'30

guselkumab

NAVIGATEP3

An Efficacy and Safety of Guselkumab in Participants With Palmoplantar PustulosisP3

A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic ArthritisP3

GALAXIP2

BIOLOPTIM-GUSP4

NOVAP2

VEGAP2

GUIDEP3

COSMOSP3

QUASARP2

COBRAP4

APEXP3

GRAVITIP3

QUASAR JrP3

CHARGEP3

DUET ENCORE-CDP3

Upcoming readouts

3 ahead · guselkumab

Select a trial to load its full ClinicalTrials.gov record.

Key guselkumab trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

Trial	Title	Phase	Status	Primary completion
NCT04080648	BIOLOPTIM-GUS: Therapeutic Drug Monitoring of Guselkumab in Psoriasis Patients	Phase 4	Completed	Dec 2023
NCT04533737	COBRA: Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis …	Phase 4	Terminated	Sept 2022
NCT07577843	DUET ENCORE-CD: A Study of JNJ-78934804 in Participants With Moderately to Severely Active Crohn's Disease	Phase 3	Recruiting	Jun 2028
NCT07499232	CHARGE: A Study of Guselkumab Versus Risankizumab in Participants With Moderately to Severely Active Cro…	Phase 3	Recruiting	Nov 2028
NCT05197049	GRAVITI: A Study of Guselkumab Subcutaneous Therapy in Participants With Moderately to Severely Active Cr…	Phase 3	Active, not recruiting	Jul 2023
NCT04882098	APEX: A Study of Guselkumab in Participants With Active Psoriatic Arthritis	Phase 3	Active, not recruiting	Dec 2024
NCT06260163	QUASAR Jr: A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Ulcerative Co…	Phase 3	Active, not recruiting	Feb 2027
NCT02203032	NAVIGATE: A Study of Guselkumab in Participants With Moderate to Severe Plaque-type Psoriasis and an Inade…	Phase 3	Completed	Dec 2015
NCT02641730	An Efficacy and Safety of Guselkumab in Participants With Palmoplantar Pustulosis	Phase 3	Completed	Mar 2017
NCT03158285	A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Particip…	Phase 3	Completed	Feb 2019
NCT03796858	COSMOS: A Study of Guselkumab in Participants With Active Psoriatic Arthritis and an Inadequate Response…	Phase 3	Completed	Nov 2020
NCT03818035	GUIDE: A Study to Evaluate Further Therapeutic Strategies With Guselkumab in Participants With Moderate…	Phase 3	Completed	Mar 2022

Track guselkumab with ComplyRx

Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

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FAQ

How many clinical trials are running for guselkumab?: ClinicalTrials.gov lists more than 16 phase 2–4 guselkumab trials. This page tracks the 16 largest by enrolment: 4 phase 2, 10 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.
Are there clinical trials for Tremfya?: Tremfya is the brand name for guselkumab, so guselkumab trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 guselkumab trials. This page tracks the 16 largest by enrolment: 4 phase 2, 10 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.
Where does this data come from?: All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare guselkumab against other drugs?: Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Upcoming readouts

Key guselkumab trials

Track guselkumab with ComplyRx

Related drug pipelines

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