8
Phase 2–4 trials
Lipid & Lp(a) therapies · Live ClinicalTrials.gov data
Olezarsen (Tryngolza) clinical trial pipeline
ClinicalTrials.gov lists 8 phase 2–4 trials for olezarsen. The next phase 3 primary completion among them is expected Mar 2027. Refreshed daily — add up to four competitors to compare pipelines side by side.
7
Phase 3 trials
0
Actively recruiting
Mar 2027
Next phase 3 primary completion
3,730
Participants across trials
Ionis Pharmaceuticals, Inc.
Lead sponsor by trial count
olezarsen (8)3 active2020–2029
olezarsen
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olezarsen
BALANCEP3
A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe HypertriglyceridemiaP3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)P3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With VolanesorsenP3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe HypertriglyceridemiaP2
A Study of Olezarsen Administered Subcutaneously to Participants With Severe HypertriglyceridemiaP3
A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe HypertriglyceridemiaP3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)P3
Upcoming readouts
3 ahead · olezarsen
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Key olezarsen trials
Top 8 of the 8 registered phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT05681351 | CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertrig… | Phase 3 | Active, not recruiting | Mar 2027 |
| NCT05185843 | A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemi… | Phase 3 | Active, not recruiting | Jun 2027 |
| NCT05130450 | A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndr… | Phase 3 | Active, not recruiting | Feb 2028 |
| NCT04568434 | BALANCE — A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) Administered to Patients With Familial Chylomicrone… | Phase 3 | Completed | Jul 2023 |
| NCT05610280 | A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascula… | Phase 3 | Completed | Aug 2024 |
| NCT05079919 | A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe Hypertriglyceridemia | Phase 3 | Completed | Oct 2024 |
| NCT05552326 | A Study of Olezarsen Administered Subcutaneously to Participants With Severe Hypertriglyceridemia | Phase 3 | Completed | Dec 2024 |
| NCT05355402 | A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atheroscler… | Phase 2 | Completed | Mar 2023 |
Related drug pipelines
FAQ
- How many clinical trials are running for olezarsen?
- ClinicalTrials.gov currently lists 8 phase 2–4 olezarsen trials: 1 phase 2, 7 phase 3, and 0 phase 4. 0 are actively recruiting.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare olezarsen against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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