How many clinical trials are running for vutrisiran?

ClinicalTrials.gov currently lists 5 phase 2–4 vutrisiran trials: 1 phase 2, 4 phase 3, and 0 phase 4. 1 are actively recruiting.

Where does this data come from?

All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.

Can I compare vutrisiran against other drugs?

Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Cardiomyopathy & ATTR amyloidosis · Live ClinicalTrials.gov data

Vutrisiran (Amvuttra) clinical trial pipeline

ClinicalTrials.gov lists 5 phase 2–4 trials for vutrisiran, 1 of them actively recruiting. The next phase 3 primary completion among them is expected Dec 2027. Refreshed daily — add up to four competitors to compare pipelines side by side.

Phase 2–4 trials

Phase 3 trials

Actively recruiting

Dec 2027

Next phase 3 primary completion

1,654

Participants across trials

Alnylam Pharmaceuticals

Lead sponsor by trial count

vutrisiran (5)3 active2019–2029

Hide completed

vutrisiran

Key

Actual date

Anticipated

Forecast to primary completion

RecruitingActive, not recruitingEnrolling by invitationCompleted

'19

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vutrisiran

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)P3

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3

Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTRP2

A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3

TRITON-PNP3

Upcoming readouts

2 ahead · vutrisiran

Select a trial to load its full ClinicalTrials.gov record.

Key vutrisiran trials

Top 5 of the 5 registered phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.

Trial	Title	Phase	Status	Primary completion
NCT07223203	TRITON-PN — TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin…	Phase 3	Recruiting	Dec 2027
NCT04153149	HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy	Phase 3	Active, not recruiting	May 2024
NCT06679946	A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy	Phase 3	Enrolling by invitation	Mar 2028
NCT03759379	HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amy…	Phase 3	Completed	Nov 2020
NCT05635045	Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR	Phase 2	Completed	May 2024

Compare vutrisiran vs mavacamten Compare vutrisiran vs aficamten

FAQ

How many clinical trials are running for vutrisiran?: ClinicalTrials.gov currently lists 5 phase 2–4 vutrisiran trials: 1 phase 2, 4 phase 3, and 0 phase 4. 1 are actively recruiting.
Where does this data come from?: All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare vutrisiran against other drugs?: Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

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