5
Phase 2–4 trials
Cardiomyopathy & ATTR amyloidosis · Live ClinicalTrials.gov data
Vutrisiran (Amvuttra) clinical trial pipeline
ClinicalTrials.gov lists 5 phase 2–4 trials for vutrisiran (Amvuttra), 1 of them actively recruiting. The next phase 3 primary completion among them is expected Dec 2027. Refreshed daily. Add up to four competitors to compare pipelines side by side.
4
Phase 3 trials
1
Actively recruiting
Dec 2027
Next phase 3 primary completion
1,654
Participants across trials
Alnylam Pharmaceuticals
Lead sponsor by trial count
vutrisiran (5)3 active2019–2029
vutrisiran
'19
'20
'21
'22
'23
'24
'25
'26
'27
'28
'29
vutrisiran
HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)P3
HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3
Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTRP2
A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With CardiomyopathyP3
TRITON-PNP3
Upcoming readouts
2 ahead · vutrisiran
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Key vutrisiran trials
Top 5 of the 5 registered phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT07223203 | TRITON-PN: TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary… | Phase 3 | Recruiting | Dec 2027 |
| NCT04153149 | HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiom… | Phase 3 | Active, not recruiting | May 2024 |
| NCT06679946 | A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy | Phase 3 | Enrolling by invitation | Mar 2028 |
| NCT03759379 | HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloido… | Phase 3 | Completed | Nov 2020 |
| NCT05635045 | Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR | Phase 2 | Completed | May 2024 |
Track vutrisiran with ComplyRx
Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.
Related drug pipelines
FAQ
- How many clinical trials are running for vutrisiran?
- ClinicalTrials.gov currently lists 5 phase 2–4 vutrisiran trials: 1 phase 2, 4 phase 3, and 0 phase 4. 1 are actively recruiting.
- Are there clinical trials for Amvuttra?
- Amvuttra is the brand name for vutrisiran, so vutrisiran trials on ClinicalTrials.gov cover it. ClinicalTrials.gov currently lists 5 phase 2–4 vutrisiran trials: 1 phase 2, 4 phase 3, and 0 phase 4. 1 are actively recruiting.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare vutrisiran against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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