Cardiomyopathy & ATTR amyloidosis · Live ClinicalTrials.gov data

Tafamidis (Vyndaqel) clinical trial pipeline

ClinicalTrials.gov lists 13 phase 2–4 trials for tafamidis (Vyndaqel), 1 of them actively recruiting. Refreshed daily. Add up to four competitors to compare pipelines side by side.

13

Phase 2–4 trials

5

Phase 3 trials

1

Actively recruiting

4,077

Participants across trials

Pfizer

Lead sponsor by trial count

tafamidis (13)3 active20072029
tafamidis
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingCompletedUnknown status
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tafamidis
Safety and Efficacy Study of Fx-1006A in Patients With Familial AmyloidosisP2
An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid PolyneuropathyP2
The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyP2
Safety And Efficacy Evaluation Of Fx-1006A In Subjects With Transthyretin AmyloidosisP3
The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M TransthyretinP3
ATTR-ACTP3
Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyP3
CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)P3
The Effect of Tafamidis on Transthyretin Stabilization, Safety, Tolerability and Efficacy in Transthyretin Amyloid Polyneuropathy PatientsP4
A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyretin Amyloid Cardiomyopathy (ATTR-CM)P4
Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTRP2
Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyloidosis Post Orthotopic Heart TransplantationP4
To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients With Transthyretin Amyloid PolyneuropathyP4

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Key tafamidis trials

Top 12 of the 13 registered phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT06940336To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adu…Phase 4RecruitingJan 2028
NCT05489523Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyl…Phase 4Active, not recruitingMay 2027
NCT04814186A Study to Assess the Safety and Efficacy Of Tafamidis In Chinese Participants With Transthyreti…Phase 4CompletedOct 2023
NCT04963985The Effect of Tafamidis on Transthyretin Stabilization, Safety, Tolerability and Efficacy in Tra…Phase 4UnknownJun 2022
NCT01435655The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V…Phase 3CompletedFeb 2014
NCT01994889ATTR-ACT: Safety and Efficacy of Tafamidis in Patients With Transthyretin CardiomyopathyPhase 3CompletedFeb 2018
NCT00925002Safety And Efficacy Evaluation Of Fx-1006A In Subjects With Transthyretin AmyloidosisPhase 3CompletedJul 2020
NCT02791230Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyPhase 3CompletedOct 2023
NCT04136171CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as…Phase 3CompletedMar 2026
NCT00791492An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Pa…Phase 2CompletedAug 2008
NCT00409175Safety and Efficacy Study of Fx-1006A in Patients With Familial AmyloidosisPhase 2CompletedMay 2009
NCT00694161The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients…Phase 2CompletedJan 2010

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FAQ

How many clinical trials are running for tafamidis?
ClinicalTrials.gov currently lists 13 phase 2–4 tafamidis trials: 4 phase 2, 5 phase 3, and 4 phase 4. 1 are actively recruiting.
Are there clinical trials for Vyndaqel?
Vyndaqel is the brand name for tafamidis, so tafamidis trials on ClinicalTrials.gov cover it. ClinicalTrials.gov currently lists 13 phase 2–4 tafamidis trials: 4 phase 2, 5 phase 3, and 4 phase 4. 1 are actively recruiting.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare tafamidis against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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