14
Phase 2–4 trials
Cardiomyopathy & ATTR amyloidosis · Live ClinicalTrials.gov data
Tafamidis (Vyndaqel) clinical trial pipeline
ClinicalTrials.gov lists 14 phase 2–4 trials for tafamidis, 2 of them actively recruiting. Refreshed daily — add up to four competitors to compare pipelines side by side.
6
Phase 3 trials
2
Actively recruiting
4,321
Participants across trials
Pfizer
Lead sponsor by trial count
tafamidis (14)5 active2008–2029
tafamidis
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tafamidis
An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Transthyretin Amyloid PolyneuropathyP2
The Effects Of Fx-1006A On Transthyretin Stabilization And Clinical Outcome Measures In Patients With V122I Or Wild-Type TTR Amyloid CardiomyopathyP2
Safety And Efficacy Evaluation Of Fx-1006A In Subjects With Transthyretin AmyloidosisP3
The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M TransthyretinP3
ATTR-ACTP3
Long-term Safety of Tafamidis in Subjects With Transthyretin CardiomyopathyP3
APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)P3
CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)P3
The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy PatientsP4
The Effect of Tafamidis on Transthyretin Stabilization, Safety, Tolerability and Efficacy in Transthyretin Amyloid Polyneuropathy PatientsP4
Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTRP2
Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyloidosis Post Orthotopic Heart TransplantationP4
To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients With Transthyretin Amyloid PolyneuropathyP4
ACO-SWITCHP4
Upcoming readouts
3 ahead · tafamidis
Select a trial to load its full ClinicalTrials.gov record.
Key tafamidis trials
Top 12 of the 14 registered phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT07298044 | ACO-SWITCH — A Study to Learn More About the Change in the Blood Levels of Transthyretin When Participants With Transthyret… | Phase 4 | Recruiting | Jul 2027 |
| NCT06940336 | To Evaluate the Efficacy and Safety of Tafamidis Meglumine Soft Capsules in the Treatment of Adult Patients Wi… | Phase 4 | Recruiting | Jan 2028 |
| NCT05489523 | Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyloidosis Post O… | Phase 4 | Active, not recruiting | May 2027 |
| NCT04828993 | The Effect Of Tafamidis Meglumine In Transthyretin Amyloid Polyneuropathy Patients | Phase 4 | Completed | Feb 2023 |
| NCT04963985 | The Effect of Tafamidis on Transthyretin Stabilization, Safety, Tolerability and Efficacy in Transthyretin Amy… | Phase 4 | Unknown | Jun 2022 |
| NCT04136171 | CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, I… | Phase 3 | Active, not recruiting | Apr 2026 |
| NCT01435655 | The Effect Of Tafamidis For The Transthyretin Amyloid Polyneuropathy Patients With V30M Or Non-V30M Transthyre… | Phase 3 | Completed | Feb 2014 |
| NCT01994889 | ATTR-ACT — Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy | Phase 3 | Completed | Feb 2018 |
| NCT00925002 | Safety And Efficacy Evaluation Of Fx-1006A In Subjects With Transthyretin Amyloidosis | Phase 3 | Completed | Jul 2020 |
| NCT03997383 | APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (AT… | Phase 3 | Completed | Jun 2022 |
| NCT02791230 | Long-term Safety of Tafamidis in Subjects With Transthyretin Cardiomyopathy | Phase 3 | Completed | Oct 2023 |
| NCT00791492 | An Extension of Study Fx-005 Evaluating Long-Term Safety And Clinical Outcomes Of Fx-1006A In Patients With Tr… | Phase 2 | Completed | Aug 2008 |
Related drug pipelines
FAQ
- How many clinical trials are running for tafamidis?
- ClinicalTrials.gov currently lists 14 phase 2–4 tafamidis trials: 3 phase 2, 6 phase 3, and 5 phase 4. 2 are actively recruiting.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare tafamidis against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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