16+
Major trials tracked
Two leading GLP-1 therapies for obesity and type 2 diabetes
Semaglutide vs tirzepatide: trial pipelines compared
A side-by-side view of the semaglutide and tirzepatide clinical trial pipelines, built from live ClinicalTrials.gov data and refreshed daily. ClinicalTrials.gov lists 16+ phase 2–4 trials for semaglutide and 16+ for tirzepatide. Add up to three more drugs to widen the comparison.
semaglutide (16) vs tirzepatide (16)11 active2013–2030
semaglutidetirzepatide
'13
'15
'17
'19
'21
'23
'25
'27
'29
semaglutide
SUSTAIN™ 2P3
SUSTAIN™1P3
PIONEER 1P3
SUSTAIN 10P3
SUSTAINP3
STEP 1P3
STEP 3P3
STEP 8P3
PIONEER PLUSP3
SEMPATICOP2
ASSETP2
ACHIEVE-3P3
A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose WeightP3
Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes MellitusP3
A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With ObesityP3
Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 DiabetesP3
tirzepatide
SURPASS-4P3
SYNERGY-NASHP2
SURMOUNT-3P3
SURMOUNT-CNP3
SURPASS-CN-INSP3
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)P3
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With ObesityP2
T-RAMP4
STOP KNEE-OAP4
Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight ParticipantsP2
SURPASS-T1D-1P3
Weekly GLP-1 Receptor Agonists in Obese Individuals Without DiabetesP3
Multi-Site Trial of Tirzepatide for Smoking CessationP2
AI-LIFE-T2D-OBP4
Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or ObeseP2
TOPAZP2
Upcoming readouts
8 ahead · 2 drugs
Select a trial to load its full ClinicalTrials.gov record.
Head to head
Registered phase 2–4 trial activity for each drug, computed from live ClinicalTrials.gov data.
semaglutide (Ozempic / Wegovy)GLP-1 & incretin therapies
14
Phase 3 trials
1
Actively recruiting
Dec 2026
Next phase 3 readout
tirzepatide (Mounjaro / Zepbound)GLP-1 & incretin therapies
16+
Major trials tracked
7
Phase 3 trials
1
Actively recruiting
Nov 2026
Next phase 3 readout
Key trials across both drugs
Top 16 registered phase 2–4 trials across semaglutide and tirzepatide, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.
Track semaglutide and tirzepatide with ComplyRx
Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.
Individual pipelines and other comparisons
FAQ
- How do the semaglutide and tirzepatide clinical pipelines compare?
- ClinicalTrials.gov currently lists 16+ phase 2–4 trials for semaglutide and 16+ for tirzepatide. The timeline above plots both side by side and refreshes daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily. ComplyRx does not add efficacy or superiority claims; the comparison shows registered trial activity only.
- Can I add more drugs to the comparison?
- Yes. The tool above compares up to five drugs on one timeline, with PNG and PDF export. Add any competitor in the search box.
