16+
Major trials tracked
Two leading GLP-1 therapies for obesity and type 2 diabetes
Semaglutide vs tirzepatide: trial pipelines compared
A side-by-side view of the semaglutide and tirzepatide clinical trial pipelines, built from live ClinicalTrials.gov data and refreshed daily. ClinicalTrials.gov lists 16+ phase 2–4 trials for semaglutide and 16+ for tirzepatide. Add up to three more drugs to widen the comparison.
semaglutide (16) vs tirzepatide (16)15 active2008–2032
semaglutidetirzepatide
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semaglutide
A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and LiraglutideP2
SUSTAIN™P3
PIONEER 7P3
Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis.P2
PIONEER 8P3
A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes.P2
A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Insulin Glargine Taken Daily With Insulin Aspart (COMBINE 3)P3
A Research Study to Compare Two Semaglutide Medicines in People With Type 2 DiabetesP3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorP3
COMBINE 4P3
Steno1P3
A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney DiseaseP2
A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 DiabetesP3
Improved Treatment and Monitoring of Alzheimer's DiseaseP2
A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesP2
UNIGUIDE-2P3
tirzepatide
SURMOUNT-1P3
SURMOUNT-OSAP3
SURPASS-SWITCHP4
A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and ObesityP2
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorP3
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)P3
A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)P4
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 DiabetesP2
TOGETHER-PsOP3
STOP KNEE-OAP4
GYMINDAP2
TABP2
SURMOUNT-1P3
A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or ObesityP4
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)P4
AI-LIFE-T2D-OBP4
Upcoming readouts
12 ahead · 2 drugs
Select a trial to load its full ClinicalTrials.gov record.
Head to head
Registered phase 2–4 trial activity for each drug, computed from live ClinicalTrials.gov data.
semaglutide (Ozempic / Wegovy)GLP-1 & incretin therapies
10
Phase 3 trials
3
Actively recruiting
Feb 2028
Next phase 3 readout
tirzepatide (Mounjaro / Zepbound)GLP-1 & incretin therapies
16+
Major trials tracked
6
Phase 3 trials
4
Actively recruiting
Feb 2027
Next phase 3 readout
Key trials across both drugs
Top 16 registered phase 2–4 trials across semaglutide and tirzepatide, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Drug | Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|---|
| tirzepatide | NCT06191848 | STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE… | Phase 4 | Recruiting | May 2027 |
| tirzepatide | NCT07438444 | A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Me… | Phase 4 | Recruiting | Oct 2027 |
| tirzepatide | NCT07697391 | AI-LIFE-T2D-OB: AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Dia… | Phase 4 | Not yet recruiting | Oct 2027 |
| tirzepatide | NCT07555730 | AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With… | Phase 4 | Not yet recruiting | Sept 2028 |
| tirzepatide | NCT05564039 | SURPASS-SWITCH: A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dul… | Phase 4 | Completed | Jul 2024 |
| tirzepatide | NCT06605703 | A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Wei… | Phase 4 | Completed | Feb 2026 |
| tirzepatide | NCT07481747 | SURMOUNT-1: Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obe… | Phase 3 | Recruiting | Feb 2027 |
| semaglutide | NCT06082063 | Steno1: Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes | Phase 3 | Recruiting | Jul 2029 |
| semaglutide | NCT07271251 | A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and E… | Phase 3 | Active, not recruiting | Jun 2026 |
| semaglutide | NCT07653477 | UNIGUIDE-2: Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Co… | Phase 3 | Not yet recruiting | Feb 2028 |
| semaglutide | NCT02254291 | SUSTAIN™: A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Dai… | Phase 3 | Completed | Nov 2015 |
| semaglutide | NCT03021187 | PIONEER 8: Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus… | Phase 3 | Completed | Jan 2018 |
| semaglutide | NCT02849080 | PIONEER 7: Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evalu… | Phase 3 | Completed | Feb 2018 |
| tirzepatide | NCT04184622 | SURMOUNT-1: A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight | Phase 3 | Completed | Apr 2022 |
| semaglutide | NCT05478252 | A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes | Phase 3 | Completed | Aug 2023 |
| semaglutide | NCT05013229 | A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insu… | Phase 3 | Completed | Nov 2023 |
Individual pipelines and other comparisons
FAQ
- How do the semaglutide and tirzepatide clinical pipelines compare?
- ClinicalTrials.gov currently lists 16+ phase 2–4 trials for semaglutide and 16+ for tirzepatide. The timeline above plots both side by side and refreshes daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily. ComplyRx does not add efficacy or superiority claims; the comparison shows registered trial activity only.
- Can I add more drugs to the comparison?
- Yes. The tool above compares up to five drugs on one timeline, with PNG and PDF export. Add any competitor in the search box.