16+
Major trials tracked
GLP-1 & incretin therapies · Live ClinicalTrials.gov data
Tirzepatide (Mounjaro / Zepbound) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 tirzepatide trials on ClinicalTrials.gov by enrolment, 7 of them actively recruiting. The next phase 3 primary completion among them is expected Oct 2027. Refreshed daily — add up to four competitors to compare pipelines side by side.
6
Phase 3 trials
7
Actively recruiting
Oct 2027
Next phase 3 primary completion
11,929
Participants across trials
Eli Lilly and Company
Lead sponsor by trial count
tirzepatide (16)10 active2021–2032
tirzepatide
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tirzepatide
SURMOUNT-2P3
SURMOUNT-3P3
SURMOUNT-OSAP3
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightP2
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorP3
A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)P3
A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial)P4
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 DiabetesP2
T-RAMP4
A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)P4
Glucagon-Like Peptide-1 Receptor Agonist in ADPKDP2
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)P3
LOCITTP2
PERIODSP4
A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLDP2
CLARAP2
Upcoming readouts
9 ahead · tirzepatide
Select a trial to load its full ClinicalTrials.gov record.
Key tirzepatide trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT06864026 | A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Ac… | Phase 4 | Recruiting | Nov 2027 |
| NCT07326111 | PERIODS — A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are … | Phase 4 | Recruiting | Dec 2028 |
| NCT06605703 | A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management… | Phase 4 | Completed | Feb 2026 |
| NCT06635057 | T-RAM — A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan | Phase 4 | Completed | Apr 2026 |
| NCT06439277 | A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2) | Phase 3 | Recruiting | Oct 2027 |
| NCT07165028 | A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (… | Phase 3 | Recruiting | Aug 2030 |
| NCT04657003 | SURMOUNT-2 — A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight | Phase 3 | Completed | Mar 2023 |
| NCT04657016 | SURMOUNT-3 — A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program | Phase 3 | Completed | Apr 2023 |
| NCT05412004 | SURMOUNT-OSA — Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstruct… | Phase 3 | Completed | Mar 2024 |
| NCT06221969 | A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in Peopl… | Phase 3 | Completed | Mar 2026 |
| NCT06143956 | A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants W… | Phase 2 | Recruiting | Sept 2027 |
| NCT06582875 | Glucagon-Like Peptide-1 Receptor Agonist in ADPKD | Phase 2 | Recruiting | Jun 2029 |
Related drug pipelines
FAQ
- How many clinical trials are running for tirzepatide?
- ClinicalTrials.gov lists more than 16 phase 2–4 tirzepatide trials. This page tracks the 16 largest by enrolment: 6 phase 2, 6 phase 3, and 4 phase 4 among them, with 7 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare tirzepatide against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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