GLP-1 & incretin therapies · Live ClinicalTrials.gov data

Tirzepatide (Mounjaro / Zepbound) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 tirzepatide (Mounjaro and Zepbound) trials on ClinicalTrials.gov by enrolment, 2 of them actively recruiting. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

9

Phase 3 trials

2

Actively recruiting

9,182

Participants across trials

Eli Lilly and Company

Lead sponsor by trial count

tirzepatide (16)7 active20172029
tirzepatide
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingCompleted
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tirzepatide
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes MellitusP2
A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 DiabetesP3
SURPASS-3P3
SURPASS-5P3
SURMOUNT-OSAP3
SURPASS-CN-INSP3
TREASURE-CKDP2
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related ComorbiditiesP3
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightP2
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose WeightP3
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)P3
REIMAGINE 5P3
STOP KNEE-OAP4
STAY-LEANP4
GYMINDAP2
LOCITTP2

Upcoming readouts

5 ahead · tirzepatide

Select a trial to load its full ClinicalTrials.gov record.

Key tirzepatide trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT06191848STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE…Phase 4RecruitingMay 2027
NCT06854614STAY-LEAN: Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and M…Phase 4Active, not recruitingApr 2027
NCT06075667A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Ov…Phase 3Active, not recruitingJun 2026
NCT03882970SURPASS-3: A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 DiabetesPhase 3CompletedDec 2020
NCT04039503SURPASS-5: A Study of Tirzepatide (LY3298176) Versus Placebo in Participants With Type 2 Diabetes Inadequat…Phase 3CompletedDec 2020
NCT03861039A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 DiabetesPhase 3CompletedJan 2021
NCT05412004SURMOUNT-OSA: Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants…Phase 3CompletedMar 2024
NCT05691712SURPASS-CN-INS: A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 DiabetesPhase 3CompletedJul 2024
NCT06584916A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Ob…Phase 3CompletedNov 2025
NCT06131437A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Los…Phase 3CompletedDec 2025
NCT06534411REIMAGINE 5: A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzep…Phase 3CompletedJun 2026
NCT06143956A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult …Phase 2RecruitingSept 2027

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Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

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FAQ

How many clinical trials are running for tirzepatide?
ClinicalTrials.gov lists more than 16 phase 2–4 tirzepatide trials. This page tracks the 16 largest by enrolment: 5 phase 2, 9 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.
Are there clinical trials for Mounjaro and Zepbound?
Mounjaro and Zepbound are brand names for tirzepatide, so tirzepatide trials on ClinicalTrials.gov cover them. ClinicalTrials.gov lists more than 16 phase 2–4 tirzepatide trials. This page tracks the 16 largest by enrolment: 5 phase 2, 9 phase 3, and 2 phase 4 among them, with 2 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare tirzepatide against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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