GLP-1 & incretin therapies · Live ClinicalTrials.gov data

Tirzepatide (Mounjaro / Zepbound) clinical trial pipeline

The timeline below tracks the 16 largest phase 2–4 tirzepatide (Mounjaro and Zepbound) trials on ClinicalTrials.gov by enrolment, 1 of them actively recruiting. The next phase 3 primary completion among them is expected Nov 2026. Refreshed daily. Add up to four competitors to compare pipelines side by side.

16+

Major trials tracked

7

Phase 3 trials

1

Actively recruiting

Nov 2026

Next phase 3 primary completion

7,270

Participants across trials

Eli Lilly and Company

Lead sponsor by trial count

tirzepatide (16)6 active2018–2030
tirzepatide
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompleted
'18
'19
'20
'21
'22
'23
'24
'25
'26
'27
'28
'29
'30
tirzepatide
SURPASS-4P3
SYNERGY-NASHP2
SURMOUNT-3P3
SURMOUNT-CNP3
SURPASS-CN-INSP3
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)P3
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With ObesityP2
T-RAMP4
STOP KNEE-OAP4
Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight ParticipantsP2
SURPASS-T1D-1P3
Weekly GLP-1 Receptor Agonists in Obese Individuals Without DiabetesP3
Multi-Site Trial of Tirzepatide for Smoking CessationP2
AI-LIFE-T2D-OBP4
Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or ObeseP2
TOPAZP2

Upcoming readouts

6 ahead · tirzepatide

Select a trial to load its full ClinicalTrials.gov record.

Key tirzepatide trials

Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

TrialTitlePhaseStatusPrimary completion
NCT06191848STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE…Phase 4Active, not recruitingMay 2027
NCT07697391AI-LIFE-T2D-OB: AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Dia…Phase 4Not yet recruitingOct 2027
NCT06635057T-RAM: A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During RamadanPhase 4CompletedApr 2026
NCT06914895SURPASS-T1D-1: A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obes…Phase 3Active, not recruitingNov 2026
NCT03730662SURPASS-4: A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participant…Phase 3CompletedJan 2021
NCT05024032SURMOUNT-CN: A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obes…Phase 3CompletedDec 2022
NCT04657016SURMOUNT-3: A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss ProgramPhase 3CompletedApr 2023
NCT05691712SURPASS-CN-INS: A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 DiabetesPhase 3CompletedJul 2024
NCT05963022A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO…Phase 3CompletedOct 2024
NCT07834398Weekly GLP-1 Receptor Agonists in Obese Individuals Without DiabetesPhase 3CompletedApr 2026
NCT07602699Multi-Site Trial of Tirzepatide for Smoking CessationPhase 2RecruitingMar 2028
NCT06732245Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or ObesePhase 2Not yet recruitingAug 2027

Track tirzepatide with ComplyRx

Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

Track tirzepatide

FAQ

How many clinical trials are running for tirzepatide?
ClinicalTrials.gov lists more than 16 phase 2–4 tirzepatide trials. This page tracks the 16 largest by enrolment: 6 phase 2, 7 phase 3, and 3 phase 4 among them, with 1 actively recruiting. Updated daily.
Are there clinical trials for Mounjaro and Zepbound?
Mounjaro and Zepbound are brand names for tirzepatide, so tirzepatide trials on ClinicalTrials.gov cover them. ClinicalTrials.gov lists more than 16 phase 2–4 tirzepatide trials. This page tracks the 16 largest by enrolment: 6 phase 2, 7 phase 3, and 3 phase 4 among them, with 1 actively recruiting. Updated daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
Can I compare tirzepatide against other drugs?
Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.

Keep following
what matters.

Choose the drugs, companies or disease areas you follow. Bring trial changes and upcoming readouts into one watch.

Build your watch

Choose what to track in the watch builder.