A GLP-1/amylin combination against a GLP-1/GIP dual agonist

Cagrilintide vs tirzepatide: trial pipelines compared

A side-by-side view of the cagrilintide and tirzepatide clinical trial pipelines, built from live ClinicalTrials.gov data and refreshed daily. ClinicalTrials.gov lists 16+ phase 2–4 trials for cagrilintide and 16+ for tirzepatide. Add up to three more drugs to widen the comparison.

cagrilintide (16) vs tirzepatide (16)14 active20172031
cagrilintidetirzepatide
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingCompleted
'17
'19
'21
'23
'25
'27
'29
'31
cagrilintide
Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity.P2
REDEFINE 1P3
REDEFINE 2P3
REDEFINE 3P3
A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose WeightP3
REDEFINE 6P3
REIMAGINE 2P3
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose WeightP3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorP3
A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and PlaceboP2
REIMAGINE 5P3
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With ObesityP3
A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-termP3
RENEW 2P3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body WeightP3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightP3
tirzepatide
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes MellitusP2
A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 DiabetesP3
SURPASS-3P3
SURPASS-5P3
SURMOUNT-OSAP3
SURPASS-CN-INSP3
TREASURE-CKDP2
A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related ComorbiditiesP3
A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightP2
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose WeightP3
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)P3
REIMAGINE 5P3
STOP KNEE-OAP4
STAY-LEANP4
GYMINDAP2
LOCITTP2

Upcoming readouts

11 ahead · 2 drugs

Select a trial to load its full ClinicalTrials.gov record.

Head to head

Registered phase 2–4 trial activity for each drug, computed from live ClinicalTrials.gov data.

cagrilintideGLP-1 & incretin therapies
16+

Major trials tracked

14

Phase 3 trials

2

Actively recruiting

Mar 2027

Next phase 3 readout

tirzepatide (Mounjaro / Zepbound)GLP-1 & incretin therapies
16+

Major trials tracked

9

Phase 3 trials

2

Actively recruiting

None scheduled

Next phase 3 readout

Key trials across both drugs

Top 16 registered phase 2–4 trials across cagrilintide and tirzepatide, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

DrugTrialTitlePhaseStatusPrimary completion
tirzepatideNCT06191848STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE…Phase 4RecruitingMay 2027
tirzepatideNCT06854614STAY-LEAN: Sequential or CombinaTion Anti-obesitY Medication With Muscle Preservation for Weight Loss and M…Phase 4Active, not recruitingApr 2027
cagrilintideNCT07564414A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Hel…Phase 3RecruitingFeb 2028
cagrilintideNCT07253285A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Ex…Phase 3RecruitingMar 2030
cagrilintideNCT05567796REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose WeightPhase 3Active, not recruitingOct 2024
tirzepatideNCT06075667A Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Ov…Phase 3Active, not recruitingJun 2026
cagrilintideNCT07011667A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and …Phase 3Active, not recruitingMar 2027
cagrilintideNCT07220759RENEW 2: Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment …Phase 3Active, not recruitingMay 2027
cagrilintideNCT05669755REDEFINE 3: REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in t…Phase 3Active, not recruitingSept 2027
cagrilintideNCT06780449A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Ob…Phase 3Active, not recruitingAug 2028
tirzepatideNCT03882970SURPASS-3: A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 DiabetesPhase 3CompletedDec 2020
tirzepatideNCT04039503SURPASS-5: A Study of Tirzepatide (LY3298176) Versus Placebo in Participants With Type 2 Diabetes Inadequat…Phase 3CompletedDec 2020
tirzepatideNCT03861039A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 DiabetesPhase 3CompletedJan 2021
tirzepatideNCT05412004SURMOUNT-OSA: Obstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants…Phase 3CompletedMar 2024
tirzepatideNCT05691712SURPASS-CN-INS: A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 DiabetesPhase 3CompletedJul 2024
cagrilintideNCT05996848REDEFINE 6: A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose We…Phase 3CompletedJan 2025

Track cagrilintide and tirzepatide with ComplyRx

Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.

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FAQ

How do the cagrilintide and tirzepatide clinical pipelines compare?
ClinicalTrials.gov currently lists 16+ phase 2–4 trials for cagrilintide and 16+ for tirzepatide. The timeline above plots both side by side and refreshes daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily. ComplyRx does not add efficacy or superiority claims; the comparison shows registered trial activity only.
Can I add more drugs to the comparison?
Yes. The tool above compares up to five drugs on one timeline, with PNG and PDF export. Add any competitor in the search box.
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