A GLP-1/amylin combination against a GLP-1/GIP dual agonist

Cagrilintide vs tirzepatide: trial pipelines compared

A side-by-side view of the cagrilintide and tirzepatide clinical trial pipelines, built from live ClinicalTrials.gov data and refreshed daily. ClinicalTrials.gov lists 16+ phase 2–4 trials for cagrilintide and 16+ for tirzepatide. Add up to three more drugs to widen the comparison.

cagrilintide (16) vs tirzepatide (16)13 active2018–2031
cagrilintidetirzepatide
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompleted
'18
'20
'22
'24
'26
'28
'30
cagrilintide
Research Study Investigating How Well NNC0174-0833 Works in People Suffering From Overweight or Obesity.P2
REDEFINE 1P3
REDEFINE 2P3
REDEFINE 3P3
A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose WeightP3
REIMAGINE 2P3
A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose WeightP3
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorP3
A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and PlaceboP2
A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose WeightP3
REIMAGINE 5P3
A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With ObesityP3
A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-termP3
RENEW 2P3
A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body WeightP3
A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightP3
tirzepatide
SURPASS-4P3
SYNERGY-NASHP2
SURMOUNT-3P3
SURMOUNT-CNP3
SURPASS-CN-INSP3
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)P3
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With ObesityP2
T-RAMP4
STOP KNEE-OAP4
Efficacy and Safety of GZR18 Every 2 Weeks Versus Tirzepatide and Placebo in Obese or Overweight ParticipantsP2
SURPASS-T1D-1P3
Weekly GLP-1 Receptor Agonists in Obese Individuals Without DiabetesP3
Multi-Site Trial of Tirzepatide for Smoking CessationP2
AI-LIFE-T2D-OBP4
Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or ObeseP2
TOPAZP2

Upcoming readouts

12 ahead · 2 drugs

Select a trial to load its full ClinicalTrials.gov record.

Head to head

Registered phase 2–4 trial activity for each drug, computed from live ClinicalTrials.gov data.

cagrilintideGLP-1 & incretin therapies
16+

Major trials tracked

14

Phase 3 trials

2

Actively recruiting

Mar 2027

Next phase 3 readout

tirzepatide (Mounjaro / Zepbound)GLP-1 & incretin therapies
16+

Major trials tracked

7

Phase 3 trials

1

Actively recruiting

Nov 2026

Next phase 3 readout

Key trials across both drugs

Top 16 registered phase 2–4 trials across cagrilintide and tirzepatide, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.

DrugTrialTitlePhaseStatusPrimary completion
tirzepatideNCT06191848STOP KNEE-OA: Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE…Phase 4Active, not recruitingMay 2027
tirzepatideNCT07697391AI-LIFE-T2D-OB: AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Dia…Phase 4Not yet recruitingOct 2027
tirzepatideNCT06635057T-RAM: A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During RamadanPhase 4CompletedApr 2026
cagrilintideNCT07564414A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Hel…Phase 3RecruitingFeb 2028
cagrilintideNCT07253285A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Ex…Phase 3RecruitingMar 2030
cagrilintideNCT05567796REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose WeightPhase 3Active, not recruitingOct 2024
tirzepatideNCT06914895SURPASS-T1D-1: A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obes…Phase 3Active, not recruitingNov 2026
cagrilintideNCT07011667A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and …Phase 3Active, not recruitingMar 2027
cagrilintideNCT07220759RENEW 2: Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment …Phase 3Active, not recruitingMay 2027
cagrilintideNCT05669755REDEFINE 3: REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in t…Phase 3Active, not recruitingSept 2027
cagrilintideNCT06780449A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Ob…Phase 3Active, not recruitingAug 2028
tirzepatideNCT03730662SURPASS-4: A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participant…Phase 3CompletedJan 2021
tirzepatideNCT05024032SURMOUNT-CN: A Study of Tirzepatide (LY3298176) in Chinese Participants Without Type 2 Diabetes Who Have Obes…Phase 3CompletedDec 2022
tirzepatideNCT04657016SURMOUNT-3: A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss ProgramPhase 3CompletedApr 2023
tirzepatideNCT05691712SURPASS-CN-INS: A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 DiabetesPhase 3CompletedJul 2024
tirzepatideNCT05963022A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO…Phase 3CompletedOct 2024

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FAQ

How do the cagrilintide and tirzepatide clinical pipelines compare?
ClinicalTrials.gov currently lists 16+ phase 2–4 trials for cagrilintide and 16+ for tirzepatide. The timeline above plots both side by side and refreshes daily.
Where does this data come from?
All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily. ComplyRx does not add efficacy or superiority claims; the comparison shows registered trial activity only.
Can I add more drugs to the comparison?
Yes. The tool above compares up to five drugs on one timeline, with PNG and PDF export. Add any competitor in the search box.

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