9
Phase 2–4 trials
Two RNA-targeted therapies for lipid and Lp(a) lowering
Olezarsen vs pelacarsen: trial pipelines compared
A side-by-side view of the olezarsen and pelacarsen clinical trial pipelines, built from live ClinicalTrials.gov data and refreshed daily. ClinicalTrials.gov lists 9 phase 2–4 trials for olezarsen and 10 for pelacarsen. Add up to three more drugs to widen the comparison.
olezarsen (9) vs pelacarsen (10)10 active2017–2032
olezarsenpelacarsen
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olezarsen
BALANCEP3
A Study of Olezarsen (ISIS 678354) Administered to Participants With Severe HypertriglyceridemiaP3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Participants With Familial Chylomicronemia Syndrome (FCS)P3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With VolanesorsenP3
A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe HypertriglyceridemiaP2
A Study of Olezarsen Administered Subcutaneously to Participants With Severe HypertriglyceridemiaP3
A Study of Olezarsen (ISIS 678354) in Participants With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease, or With Severe HypertriglyceridemiaP3
CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)P3
A Study of Olezarsen for the Treatment of Familial Chylomicronemia Syndrome (FCS) in Pediatric ParticipantsP3
pelacarsen
Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular DiseaseP2
Lp(a)HORIZONP3
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in GermanyP3
OLEP3
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve StenosisP2
Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVDP3
ADD-VANTAGEP3
Pelacarsen Roll-over Extension ProgramP3
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)P3
Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARLP3
Upcoming readouts
10 ahead · 2 drugs
Select a trial to load its full ClinicalTrials.gov record.
Head to head
Registered phase 2–4 trial activity for each drug, computed from live ClinicalTrials.gov data.
olezarsen (Tryngolza)Lipid & Lp(a) therapies
8
Phase 3 trials
1
Actively recruiting
Mar 2027
Next phase 3 readout
pelacarsenLipid & Lp(a) therapies
10
Phase 2–4 trials
8
Phase 3 trials
4
Actively recruiting
Feb 2028
Next phase 3 readout
Key trials across both drugs
Top 16 registered phase 2–4 trials across olezarsen and pelacarsen, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.
Track olezarsen and pelacarsen with ComplyRx
Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.
Individual pipelines and other comparisons
FAQ
- How do the olezarsen and pelacarsen clinical pipelines compare?
- ClinicalTrials.gov currently lists 9 phase 2–4 trials for olezarsen and 10 for pelacarsen. The timeline above plots both side by side and refreshes daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily. ComplyRx does not add efficacy or superiority claims; the comparison shows registered trial activity only.
- Can I add more drugs to the comparison?
- Yes. The tool above compares up to five drugs on one timeline, with PNG and PDF export. Add any competitor in the search box.