16+
Major trials tracked
Neuroscience · Live ClinicalTrials.gov data
Xanomeline-trospium (Cobenfy) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 xanomeline-trospium (Cobenfy) trials on ClinicalTrials.gov by enrolment, 11 of them actively recruiting. The next phase 3 primary completion among them is expected Oct 2026. Refreshed daily. Add up to four competitors to compare pipelines side by side.
16
Phase 3 trials
11
Actively recruiting
Oct 2026
Next phase 3 primary completion
7,139
Participants across trials
Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Lead sponsor by trial count
xanomeline (16)12 active2021–2031
xanomeline
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xanomeline
A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-3)P3
An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-5)P3
ARISEP3
An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of SchizophreniaP3
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)P3
Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)P3
A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)P3
BALSAM-1P3
A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)P3
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)P3
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's DiseaseP3
A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)P3
A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or LamotrigineP3
A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)P3
A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)P3
Relapse Prevention Trial Evaluating KarXT Treatment in SchizophreniaP3
Upcoming readouts
12 ahead · xanomeline
Select a trial to load its full ClinicalTrials.gov record.
Key xanomeline-trospium trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Trial names open the full ComplyRx trial page; NCT ids link to ClinicalTrials.gov.
Track xanomeline-trospium with ComplyRx
Get an alert when a trial changes status, moves its completion date, or a new trial registers in scope. Checked nightly against ClinicalTrials.gov.
Related drug pipelines
FAQ
- How many clinical trials are running for xanomeline-trospium?
- ClinicalTrials.gov lists more than 16 phase 2–4 xanomeline-trospium trials. This page tracks the 16 largest by enrolment: 0 phase 2, 16 phase 3, and 0 phase 4 among them, with 11 actively recruiting. Updated daily.
- Are there clinical trials for Cobenfy?
- Cobenfy is the brand name for xanomeline-trospium, so xanomeline-trospium trials on ClinicalTrials.gov cover it. ClinicalTrials.gov lists more than 16 phase 2–4 xanomeline-trospium trials. This page tracks the 16 largest by enrolment: 0 phase 2, 16 phase 3, and 0 phase 4 among them, with 11 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare xanomeline-trospium against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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