16+
Major trials tracked
Respiratory · Live ClinicalTrials.gov data
Tezepelumab (Tezspire) clinical trial pipeline
The timeline below tracks the 16 largest phase 2–4 tezepelumab trials on ClinicalTrials.gov by enrolment, 4 of them actively recruiting. The next phase 3 primary completion among them is expected Jul 2026. Refreshed daily — add up to four competitors to compare pipelines side by side.
12
Phase 3 trials
4
Actively recruiting
Jul 2026
Next phase 3 primary completion
8,538
Participants across trials
AstraZeneca
Lead sponsor by trial count
tezepelumab (16)8 active2013–2030
tezepelumab
'13
'15
'17
'19
'21
'23
'25
'27
'29
tezepelumab
Study to Evaluate the Efficacy and Safety of MEDI9929 (AMG 157) in Adult Subjects With Inadequately Controlled, Severe AsthmaP2
NAVIGATORP3
DESTINATIONP3
A Dose Ranging Placebo-Controlled Double-Blind Study to Evaluate the Safety and Efficacy of Tezepelumab in Atopic DermatitisP2
DIRECTIONP3
COURSEP2
WAYPOINTP3
PASSAGEP4
WAYFINDERP3
CROSSINGP3
HORIZONP3
ARRIVALP3
EMBARKP3
JOURNEYP3
Compare the Efficacy and Safety of QL2302 Versus Tezspire® in Severe AsthmaP3
TAPERP3
Upcoming readouts
7 ahead · tezepelumab
Select a trial to load its full ClinicalTrials.gov record.
Key tezepelumab trials
Top 12 of the 16 tracked phase 2–4 trials, ordered by phase and status. Each links to its full ClinicalTrials.gov record.
| Trial | Title | Phase | Status | Primary completion |
|---|---|---|---|---|
| NCT05329194 | PASSAGE — Effectiveness and Safety Study of Tezepelumab in Adults & Adolescent Participants With Severe Asthma in the Un… | Phase 4 | Completed | Oct 2025 |
| NCT07363642 | TAPER — Phase 3b Study in Patients With Severe Asthma Treated With Tezepelumab | Phase 3 | Recruiting | Aug 2027 |
| NCT06023589 | HORIZON — A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Year… | Phase 3 | Recruiting | May 2028 |
| NCT06878261 | JOURNEY — A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Seve… | Phase 3 | Recruiting | Mar 2029 |
| NCT06883305 | EMBARK — A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Seve… | Phase 3 | Recruiting | Mar 2029 |
| NCT05583227 | CROSSING — Efficacy and Safety of Tezepelumab in Patients With Eosinophilic Esophagitis | Phase 3 | Active, not recruiting | Jul 2026 |
| NCT06473779 | ARRIVAL — Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clini… | Phase 3 | Active, not recruiting | Jun 2027 |
| NCT07302516 | Compare the Efficacy and Safety of QL2302 Versus Tezspire® in Severe Asthma | Phase 3 | Not yet recruiting | Dec 2028 |
| NCT03347279 | NAVIGATOR — Study to Evaluate Tezepelumab in Adults & Adolescents With Severe Uncontrolled Asthma | Phase 3 | Completed | Sept 2020 |
| NCT03706079 | DESTINATION — Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents With Severe, … | Phase 3 | Completed | Oct 2021 |
| NCT03927157 | DIRECTION — Study to Evaluate Tezepelumab in Adults With Severe Uncontrolled Asthma | Phase 3 | Completed | May 2024 |
| NCT05274815 | WAYFINDER — Study to Evaluate Efficacy and Safety of Tezepelumab in Reducing Oral Corticosteroid Use in Adult Patients Wit… | Phase 3 | Completed | Sept 2024 |
Related drug pipelines
FAQ
- How many clinical trials are running for tezepelumab?
- ClinicalTrials.gov lists more than 16 phase 2–4 tezepelumab trials. This page tracks the 16 largest by enrolment: 3 phase 2, 12 phase 3, and 1 phase 4 among them, with 4 actively recruiting. Updated daily.
- Where does this data come from?
- All trial data is sourced from ClinicalTrials.gov (CTGov) and refreshed on this page daily.
- Can I compare tezepelumab against other drugs?
- Yes. The free ComplyRx Trial Pipeline tool compares up to five drugs side by side on one timeline, with PNG and PDF export. Add any competitor in the search box above.
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