Biotechnology company · CYTK

Cytokinetics
clinical trial
pipeline

Registry checked

Published

Aficamten is linked to 3 distinct active studies: 2 active but not recruiting, 1 enrolling by invitation. Omecamtiv Mecarbil is linked to 1 distinct active study: 1 recruiting. Ulacamten is linked to 1 distinct active study: 1 recruiting.

Phase 3 study NCT06736574 in Heart Failure and Heart Failure With Reduced Ejection Fraction lists estimated primary completion in September 2027. These are registry estimates of primary completion, not confirmed results announcements or overall study completion.

Active trial mix

Lead-sponsor scope

5active trials
as lead sponsor
  • Phase 10
  • Phase 21
  • Phase 34
  • Phase 40
  • Phase not recorded0

One highest explicitly recorded phase per active trial. Combined phases use the highest phase. Phase not recorded is shown separately.

Change history

Follow the changes behind the company’s clinical programme.

30 Sept 2026 – 29 Oct 2026 · UTC

Recorded changes

00 trials30 completed days

No eligible observations recorded in this period.

Recruitment statusPrimary completionEnrolmentFirst observedOther

Verified live registry-derived observations in completed UTC days. Recorded dates are observation dates, not necessarily registry amendment dates. Zero means no eligible observations recorded, not daily monitoring of every trial.

0 archive observations and 0 unverified observations excluded.

View exact daily values and type totals
Recorded observations in completed UTC days
Date (UTC)Recruitment statusPrimary completionEnrolmentFirst observedOtherTotalAffected trials
2026-09-300000000
2026-10-010000000
2026-10-020000000
2026-10-030000000
2026-10-040000000
2026-10-050000000
2026-10-060000000
2026-10-070000000
2026-10-080000000
2026-10-090000000
2026-10-100000000
2026-10-110000000
2026-10-120000000
2026-10-130000000
2026-10-140000000
2026-10-150000000
2026-10-160000000
2026-10-170000000
2026-10-180000000
2026-10-190000000
2026-10-200000000
2026-10-210000000
2026-10-220000000
2026-10-230000000
2026-10-240000000
2026-10-250000000
2026-10-260000000
2026-10-270000000
2026-10-280000000
2026-10-290000000
Type totals0000000 distinct

02 / Drugs & programmes

Explore the pipeline

3 selected programmes

Choose a drug to open its record in the tracker. Sign in to continue.

Aficamten

myqorzo

3
Active trials
0
Recruiting trials
Trial phases
Highest: Phase 3
  • Phase 10
  • Phase 20
  • Phase 33
  • Phase 40
  • Phase not recorded0
Studied condition
Pediatric · Symptomatic Hypertrophic Cardiomyopathy (HCM) · Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
Next primary completion
Not reported
Open drug

Omecamtiv Mecarbil

Canonical investigational asset

1
Active trials
1
Recruiting trials
Trial phases
Highest: Phase 3
  • Phase 10
  • Phase 20
  • Phase 31
  • Phase 40
  • Phase not recorded0
Studied condition
Heart Failure · Heart Failure With Reduced Ejection Fraction
Next primary completion
Sept 2027 · estimated
Open drug

Ulacamten

Canonical investigational asset

1
Active trials
1
Recruiting trials
Trial phases
Highest: Phase 2
  • Phase 10
  • Phase 21
  • Phase 30
  • Phase 40
  • Phase not recorded0
Studied condition
Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)
Next primary completion
Not reported
Open drug

5 of 5 active trials have accepted investigational programme links. Trial context does not establish ownership or complete drug coverage.

3 selected programmes · accepted investigational links cover 5 of 5 active trials · brand names checked where available.

Accepted links do not establish complete intervention mapping or ownership. Programme populations overlap.

Up to six canonical assets identified through accepted investigational links in active trials. Counts describe this trial context and do not establish ownership or a complete corporate drug portfolio. Opening a record requires sign-in and does not start tracking.

03 / Clinical trial timeline

Cytokinetics trials in progress

Registry start → study completion

◇ Recorded observation│ Primary completion milestoneHatched ends retain month / year uncertaintyHover, focus or tap an observation
Trial / programme
3 selected Phase 3 / 2 trials
2021202220232024202520262027202820292030
COMET-HF
Omecamtiv Mecarbil

NCT06736574

Phase 3 · Recruiting

Trial source and qualifications

Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Duration ends at independently recorded study completion. Registry primary completion, not a confirmed results announcement. Observation markers describe recorded observations, not scheduled completion dates. Up to three newest eligible verified observations from a bounded trailing 24-month candidate window are shown, not full history.

0 candidate observations · 0 shown · 0 recorded after primary completion · 0 unverified · 0 invalid dates · 0 before supported start · 0 outside horizon · 0 excluded by display cap · source retrieval not capped.

ClinicalTrials.gov source

No eligible observations recorded in the inspected period.

    Start: 19 Dec 2024 · actual
    Primary completion: Sept 2027 · estimated
    Study completion: Dec 2027 · estimated

    2021202220232024202520262027202820292030
    FOREST-HCM
    Aficamten

    NCT04848506

    Phase 3 · Enrolling by invitation

    Trial source and qualifications

    Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM

    Duration ends at independently recorded study completion. Registry primary completion, not a confirmed results announcement. Observation markers describe recorded observations, not scheduled completion dates. Up to three newest eligible verified observations from a bounded trailing 24-month candidate window are shown, not full history. 1 inspected observations were not displayed.

    1 candidate observations · 0 shown · 0 recorded after primary completion · 1 unverified · 0 invalid dates · 0 before supported start · 0 outside horizon · 0 excluded by display cap · source retrieval not capped.

    ClinicalTrials.gov source

    1 inspected observations omitted. At most three verified observations are shown, not full history.

      Start: 06 May 2021 · actual
      Primary completion: Mar 2029 · estimated
      Study completion: Mar 2029 · estimated

      2021202220232024202520262027202820292030
      CEDAR-HCM
      Aficamten

      NCT06412666

      Phase 3 · Active, not recruiting

      Trial source and qualifications

      A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).

      Duration ends at independently recorded study completion. Registry primary completion, not a confirmed results announcement. Observation markers describe recorded observations, not scheduled completion dates. Up to three newest eligible verified observations from a bounded trailing 24-month candidate window are shown, not full history. 3 inspected observations were not displayed.

      5 candidate observations · 2 shown · 0 recorded after primary completion · 3 unverified · 0 invalid dates · 0 before supported start · 0 outside horizon · 0 excluded by display cap · source retrieval not capped.

      ClinicalTrials.gov source

      3 inspected observations omitted. At most three verified observations are shown, not full history.

      • enrollment change · Recorded 2026-08-19 · Verified live registry-derived observation. Recorded date is not necessarily the registry amendment date. Observations outside the duration bar do not extend the study.
      • status flip · Recorded 2026-08-19 · Verified live registry-derived observation. Recorded date is not necessarily the registry amendment date. Observations outside the duration bar do not extend the study.

      Start: 29 May 2024 · actual
      Primary completion: Jan 2030 · estimated
      Study completion: Jan 2030 · estimated

      2021202220232024202520262027202820292030

      Up to six active Phase 2/3 trials with upcoming estimated primary-completion intervals, ordered by nearest interval, highest phase and NCT. Historical dates never pad this selection. Ten calendar years are shown. Dates retain registry precision and independent date types.

      3 selected of 3 eligible trials · 0 without supported dates · 0 omitted for contradictory chronology. Excluded: 1 actual primary completions, 0 untyped primary completions, 1 past estimates, 0 outside the horizon, 0 contradictory dates.

      04 / Therapeutic focus

      Where the activity is

      5

      active trials in Cardiovascular

      Primary therapeutic groups are indexed enrichment. Unmapped trials and healthy volunteers remain in the active-trial denominator.

      Active trials by primary therapeutic area

      • Cardiovascular5 trials
      • Unmapped0 trials
      • Healthy volunteers0 trials

      Each active trial counts once. Full bar equals all active trials in this lead-sponsor scope. This grouping does not describe commercial strategy.

      06 / Related companies

      All companies

      No supported overlap was identified in the selected programme context. Based on the selected programmes and indexed lead-sponsor records, not a complete ranking or a competitive/ownership assessment.

      Sources, scope and methodology

      ClinicalTrials.gov lead-sponsor scope

      Canonical current-owner attribution covers 41 distinct NCT records attributed through the canonical sponsor map. Included canonical entities: Cytokinetics. Phrases retrieve candidates only, then verbatim lead-sponsor attribution determines inclusion.

      ClinicalTrials.gov

      Attribution coverage

      41 distinct registry candidates produced 41 accepted studies. 0 mapped to other owners, 0 lacked a canonical mapping and 0 fell outside an operating subset. Accepted mappings include 41 unverified, 0 identity-only and 0 device-tagged trial memberships. Mapping flags describe evidence quality, not a separate ownership authority.

      Indexed enrichment

      41 scoped records have indexed enrichment and 0 do not. Missing enrichment does not remove a trial from cohort counts.

      Scope observation

      The successful attribution check completed at 2026-10-30T22:59:24.221Z. This is a dated canonical-attribution snapshot. Static pages normally regenerate after 24 hours, but cached HTML can outlive that interval when regeneration fails. Map changes affect the next successful regeneration. This timestamp is separate from individual registry-update dates. Snapshot 918142f6b01128e67a79f39ec90574a20ccf719fdcace4861daa91d7c9c87322.

      Active means recruiting, not yet recruiting, active not recruiting or enrolling by invitation. Recruiting counts recruiting only. Trial counts describe lead sponsorship under the published canonical-attribution policy. Identified programmes and therapeutic groups depend on available enrichment. Drug, device and other clinical studies may be included. This is the mapped company scope, not an exhaustive corporate trial census.

      Dated canonical-attribution snapshot: 41 mapped lead-sponsored clinical studies across all statuses. 41 have indexed enrichment. Drug, device and other studies may be represented. Sponsor tags do not classify trial interventions. This is the mapped company scope, not an exhaustive corporate trial census. Recorded changes may reflect observation or archive ingestion rather than a new registry amendment.

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