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inclisiran (16) vs pelacarsen (10)15 active2017–2034
inclisiranpelacarsen
Key
Actual date
Anticipated
Forecast to primary completion
RecruitingActive, not recruitingNot yet recruitingCompleted
'17
'19
'21
'23
'25
'27
'29
'31
'33
inclisiran
ORION-3P2
ORION-11P3
ORION-10P3
ORION-4P3
ORION-8P3
Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)P3
V-INCEPTIONP3
V-INITIATEP3
SPIRITP3
V-PLAQUEP3
A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.P3
V-MonoP3
PRECADP3
LATAM LOWERS LDL-CP4
V-INVINCIBLEP4
V-INTERVENTIONP4
pelacarsen
Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular DiseaseP2
Lp(a)HORIZONP3
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Rate of Weekly Lipoprotein Apheresis Sessions in Patients With Hyperlipoproteinemia(a) and Established Cardiovascular Disease in GermanyP3
OLEP3
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve StenosisP2
Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVDP3
ADD-VANTAGEP3
Pelacarsen Roll-over Extension ProgramP3
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)P3
Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARLP3

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