Big pharma · GSK · 4,008 trials led

GSK clinical trial pipeline

4,008 trials as lead sponsor, 84 recruiting now, 983 in phase 3. Live from ClinicalTrials.gov, updated daily.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
View trials

Archive historyApr 2023 to Sept 2026

85 recorded changes across GSK trials

Every status move, completion date shift and enrollment change ComplyRx has recorded across 28 of these trials. One is shown below.

Status changeStatus moved to recruiting from not yet recruitingNCT07689201 · recorded 9 Sept 2026
Track to read them

+81 more recorded changes · Track a drug to see every change the night it lands

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Most active programmes

The drugs appearing most often across GSK's recently active trials. Comparator arms are excluded.

  • GSK57842838 trials
  • Efimosfermin alfa6 trials
  • Dostarlimab6 trials
  • Depemokimab5 trials
  • Belimumab4 trials
  • Pembrolizumab4 trials

Upcoming readouts

Next primary completion dates among GSK's active phase 2 and phase 3 trials. Dates are registry estimates and move often, which is exactly what the tracker watches.

Top therapeutic areas

Conditions studied most often across GSK's recently active trials.

  • HIV Infections13 trials
  • Asthma8 trials
  • Pulmonary Disease, Chronic Obstructive5 trials
  • Nasal Polyps5 trials
  • Respiratory Syncytial Virus Infections5 trials
  • Neoplasms4 trials

GSK pipeline by phase

The main study drugs across 192 active trials GSK leads on ClinicalTrials.gov. Each drug sits in the highest phase among its currently active trials, which can be lower than a phase it has already completed.

Phase 333 drugs

GSK phase 3 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Belantamab mafodotin193Feb 2029 est.NCT06956170 · NCT06868667 · NCT06868654
GSK578428382Apr 2027 est.NCT07782996 · NCT07782970 · NCT07782957
Efimosfermin alfa65Oct 2027 est.NCT07704892 · NCT07701993 · NCT07221227
Mocertatug rezetecan53Sept 2027 est.NCT07694427 · NCT07684599 · NCT07286331
Belimumab43Aug 2029 est.NCT06716606 · NCT06572384 · NCT05878717
CAB LA3Mar 2027 est.NCT06134362 · NCT06741397 · NCT06786520
Ris-Rez33Nov 2027 est.NCT07099898 · NCT07602777 · NCT06551142
BLU-593721Aug 2027 est.NCT07650084 · NCT05600777
Cabotegravir (CAB) tablet2NCT02951052 · NCT02938520
Investigational varicella vaccine22Nov 2026 est.NCT06806137 · NCT06693895
RSVPreF3 OA vaccine2Sept 2026 est.NCT07220109 · NCT06534892
Velzatinib22Nov 2027 est.NCT07585266 · NCT07689201
BMS-6630681NCT02362503
CAB LA + RPV LA1NCT06694805
CAB ULA11Sept 2029 est.NCT07650916
Cabotegravir Tablets1NCT03299049
Candidate varicella vaccine11NCT06855160
Dolutegravir1NCT05979311
dTpa1Nov 2026 est.NCT07596199
FF/UMEC/VI11Jan 2027 est.NCT05757102
Fostemsavir11Sept 2032 est.NCT07393659
HFA-152a1Feb 2027 est.NCT07645248
HZ/su vaccine1Aug 2027 est.NCT05371080
IDRX-4211May 2028 est.NCT07218926
Investigational varicella vaccine_Lot 111Dec 2026 est.NCT06740630
Linerixibat1Sept 2026 est.NCT04167358
MMRVNS11Feb 2028 est.NCT07406360
MMRVNS vaccine1Jun 2028 est.NCT07742644
Mocertatug rezetecan (Mo-Rez)1May 2030 est.NCT07684612
mRNA Seasonal Flu vaccine1Jun 2028 est.NCT07805707
Risvutatug rezetecan (Ris-Rez)1Dec 2029 est.NCT07802704
RSVPreF3 OA investigational vaccine1NCT04732871
Tafenoquine11NCT06666491

Phase 220 drugs

GSK phase 2 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Bepirovirsen3Apr 2027 est.NCT06497504 · NCT04954859 · NCT07168356
GSK3862995B32Dec 2026 est.NCT07201051 · NCT07789899 · NCT06154837
Momelotinib32Mar 2027 est.NCT07569081 · NCT06847867 · NCT06517875
Adjuvanted RSVPreF3 vaccine2Jan 2027 est.NCT07712380 · NCT07092865
Cobolimab2Oct 2026 est.NCT04655976 · NCT06521567
GSK452722621Sept 2026 est.NCT07105709 · NCT06079190
GSK453299021Nov 2027 est.NCT06613698 · NCT05583344
VH38101092Jan 2027 est.NCT05996471 · NCT07053384
VH452418422Jun 2027 est.NCT07202546 · NCT07636928
AltSonflex1-2-31Oct 2028 est.NCT07320716
Camlipixant11Mar 2027 est.NCT07519395
Daplusiran/Tomligisiran Dose Level 11May 2027 est.NCT06537414
Efimosfermin11Jul 2028 est.NCT06920043
Flu mRNA (Formulation B1)1NCT07204964
GSK3772701 600 mg1Jul 2027 est.NCT07545681

Phase 141 drugs

GSK phase 1 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Pn-MAPS30plus31Dec 2026 est.NCT07428759 · NCT07406347 · NCT07406334
Gepotidacin2May 2027 est.NCT07645235 · NCT07371429
GSK47712612Sept 2026 est.NCT07600450 · NCT06734234
GSK592637121Mar 2028 est.NCT07607925 · NCT07371468
Risvutatug rezetecan21Jan 2028 est.NCT07602855 · NCT06885034
Aletekitug1Jul 2028 est.NCT07747480
Aletekitug (GSK1070806)1Jul 2028 est.NCT07747467
Belantamab11Aug 2028 est.NCT05714839
Belantamab SC1Aug 2027 est.NCT07742527
Cabotegravir 200 mg/mL11Jun 2027 est.NCT05418868

Phase 48 drugs

GSK phase 4 drugs, most trials first
DrugTrialsRecruitingNext readoutSample trials
Dostarlimab154Nov 2026 est.NCT07652515 · NCT06897527 · NCT07740720
Depemokimab98Sept 2026 est.NCT07701967 · NCT07671001 · NCT07456033
Niraparib51Dec 2026 est.NCT06887933 · NCT04915755 · NCT03602859
Belimumab (GSK1550188)1Jun 2027 est.NCT06411249
Fluticasone furoate/umeclidinium bromide/vilanterol trifenatate1NCT06372496
Mepolizumab1NCT06041386
Recombinant zoster vaccine11Apr 2030 est.NCT07502560
rMenB+OMV NZ1NCT06113198

Derived from 192 active trials GSK leads; 192 name an intervention, folding into 102 phased drugs. This is ComplyRx's reading of the registry, not GSK's own pipeline disclosure.

GSK trials

The 50 most significant of GSK's recently active trials, soonest estimated readout first.
Select any row for the full record; the change timeline unlocks with tracking.

TrialPhaseStabilityStatusEnrollmentEst. readout
RSV OA=ADJ=012An Extension and Crossover Vaccination Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus Given to Adults 60 Years of Age and Above Who Participated in RSV OA=ADJ-006 StudyNCT06534892RSVPreF3 OA vaccinePhase 3Locked · track to revealOngoingActive, not recruiting10,212 est.30 Sept 2026
A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant WomenNCT07596199dTpaPhase 3Locked · track to revealOngoingActive, not recruiting102 est.23 Nov 2026
A Study to Investigate the Repeat-dose Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With Ganfeborole in Female Participants of Non-childbearing PotentialNCT07784894GanfeborolePhase 1Not yet scoredOngoingNot yet recruiting28 est.24 Nov 2026
A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney TransplantNCT07092865Adjuvanted RSVPreF3 vaccinePhase 2Locked · track to revealOngoingActive, not recruiting168 est.12 Jan 2027
A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With AsthmaNCT05757102FF/UMEC/VIPhase 3Locked · track to revealOngoingRecruiting292 est.26 Jan 2027
A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Toddlers 12 to 15 Months of Age Receiving a Single Booster DoseNCT07406334Pn-MAPS30plusPhase 1Locked · track to revealOngoingRecruiting45 est.22 Feb 2027
GLIDEA Study of Depemokimab in Participants of 6 to 11 Years of AgeNCT07671001DepemokimabPhase 3Not yet scoredOngoingRecruiting34 est.1 Mar 2027
A Comparative Study to Investigate the Difference in Blood Levels of Two Different Formulations of GSK5784283NCT07712393GSK5784283Phase 1Not yet scoredOngoingRecruiting24 est.13 Apr 2027
A Study to Assess the Effectiveness and Safety of GSK3862995B in Adults With BronchiectasisNCT07201051GSK3862995BPhase 2Locked · track to revealOngoingRecruiting363 est.4 May 2027
A Phase 2b Study Evaluating Oral VH4524184 Regimens in Treatment Naïve Persons With HIV-1 (INNOVATE Study)NCT07202546VH4524184Phase 2Locked · track to revealOngoingRecruiting186 est.11 Jun 2027
Efficacy and Safety of Depemokimab Monotherapy Without Concomitant Use of Intranasal Corticosteroids (INCS) in Japanese Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)NCT07701967DepemokimabPhase 4Locked · track to revealOngoingRecruiting28 est.28 Jun 2027
A Study to Evaluate Safety, Reactogenicity, and Immunogenicity of the GSK 4-component Strep A Vaccine With Aluminum Hydroxide (Alum) or AS37 in Healthy Young AdultsNCT07085702Low dose Strep A AlumPhase 1Locked · track to revealOngoingRecruiting108 est.29 Jun 2027
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)NCT06411249Belimumab (GSK1550188)Phase 4Locked · track to revealOngoingActive, not recruiting303 est.29 Jun 2027
A Study to Evaluate the Safety, Tolerability, and Effects on Blood and Urine Markers of Single Ascending Dose of GSK4771261 in Healthy Participants and Participants With Autosomal Dominant Polycystic Kidney DiseaseNCT06734234GSK4771261Phase 1Locked · track to revealOngoingActive, not recruiting86 est.23 Jul 2027
DynaMMic-2A Study to Evaluate the Subcutaneous Belantamab (BCMAb) Formulation Versus Intravenous Belantamab in Participants With Multiple Myeloma While Treated With Standard of CareNCT07742527Belantamab SCPhase 1Not yet scoredOngoingNot yet recruiting22 est.5 Aug 2027
A Study to Investigate the Difference In Blood Levels of Camlipixant Between Different Camlipixant Formulation PrototypesNCT07684586CamlipixantPhase 1Not yet scoredStoppedWithdrawn0 est.27 Aug 2027
A Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Two GSK3862995B Formulations in Healthy ParticipantsNCT07789899GSK3862995BPhase 1Not yet scoredOngoingRecruiting24 est.7 Sept 2027
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)NCT07099898Ris-RezPhase 3Locked · track to revealOngoingRecruiting420 est.5 Nov 2027
A Study to Evaluate the Safety, Reactogenicity, and Immune Response of the GSK Vaccines Institute for Global Health (GVGH) Quadrivalent Pan-Salmonella Vaccine With and Without Alum in Healthy Young AdultsNCT07663032Pan-Salmonella-with-Alum (Low dose) vaccinePhase 1Not yet scoredOngoingRecruiting196 est.14 Nov 2027
A Study Evaluating the Efficacy and Safety of Risvutatug Rezetecan in Participants With Advanced Sarcomas (EMBOLD Sarcoma-202)NCT07602777Ris-RezPhase 1Locked · track to revealOngoingRecruiting113 est.18 Nov 2027
DESTINYDepemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety TrialNCT05334368DepemokimabPhase 3Locked · track to revealOngoingRecruiting109 est.24 Nov 2027
STARLIGHTA Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver DiseaseNCT06613698GSK4532990Phase 2Locked · track to revealOngoingRecruiting393 est.26 Nov 2027
A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and PimitespibNCT07689201VelzatinibPhase 2Locked · track to revealOngoingRecruiting24 est.29 Nov 2027
A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)NCT06885034Risvutatug RezetecanPhase 1Locked · track to revealOngoingRecruiting451 est.10 Jan 2028
First Time in Human Study of Long Acting VH4524184 FormulationsNCT06310551Oral VH4524184Phase 1Locked · track to revealOngoingRecruiting372 est.21 Jan 2028
A Study to Investigate Mocertatug Rezetecan Compared With Chemotherapy in Participants With Endometrial Cancer After Platinum-based Chemotherapy and Immunotherapy (BEHOLD-Endometrial01)NCT07286331Mocertatug rezetecanPhase 3Locked · track to revealOngoingRecruiting600 est.29 Feb 2028
ZENITH-2A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASHNCT07221188Efimosfermin AlfaPhase 3Locked · track to revealOngoingRecruiting1,250 est.24 Mar 2028
First-Time-in-Human Study of GSK5471713 in Adults With mCRPCNCT07332455GSK5471713Phase 1Locked · track to revealOngoingRecruiting54 est.24 Mar 2028
ZENITH-1A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASHNCT07221227Efimosfermin alfaPhase 3Locked · track to revealOngoingRecruiting1,200 est.29 Mar 2028
A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib TherapyNCT07218926IDRX-42Phase 3Locked · track to revealOngoingRecruiting450 est.30 May 2028
A Study on the Efficacy of a Vaccine Against Influenza in Adults ≥65 Years of AgeNCT07805707mRNA Seasonal Flu vaccinePhase 3Not yet scoredOngoingNot yet recruiting54,000 est.9 Jun 2028
MMRVNS 20-002A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of AgeNCT07742644MMRVNS vaccinePhase 3Not yet scoredOngoingNot yet recruiting1,860 est.27 Jun 2028
PEGASUSA Study to Investigate the Safety and Tolerability of Multiple Study Interventions in Participants With Moderate to Severe Ulcerative ColitisNCT07747467Aletekitug (GSK1070806)Phase 1Not yet scoredOngoingNot yet recruiting16 est.31 Jul 2028
A Sub Study to Investigate the Safety and Tolerability of Aletekitug in Participants With Moderate To Severe Ulcerative ColitisNCT07747480AletekitugPhase 1Not yet scoredOngoingNot yet recruiting16 est.31 Jul 2028
DynaMMic-1A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination TreatmentsNCT05714839BelantamabPhase 1Locked · track to revealOngoingRecruiting123 est.3 Aug 2028
ALLSTARA Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)NCT07791043Efimosfermin alfaPhase 2Not yet scoredOngoingNot yet recruiting274 est.5 Sept 2028
A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid TumorsNCT07213609GSK5460025Phase 1Locked · track to revealOngoingRecruiting47 est.28 Sept 2028
A Trial to Evaluate the Safety and Reactogenicity of an Investigational Pneumococcal Vaccine in Infants Receiving 3-dose Primary Dosing Series Followed by a Booster Dose at 12 to 15 Months of AgeNCT07406347Pn-MAPS30plusPhase 1Locked · track to revealOngoingNot yet recruiting60 est.18 Oct 2028
A Study to Investigate Pharmacokinetics (PK), Safety, and Tolerability of VH4367310 in Healthy Adult ParticipantsNCT07818915VH4367310Phase 1Not yet scoredOngoingNot yet recruiting112 est.2 Jan 2029
First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid TumorsNCT07438782GSK5533524Phase 1Locked · track to revealOngoingRecruiting97 est.6 Feb 2029
A Study to Investigate the Efficacy and Safety of GSK5784283 Compared With Placebo in Participants With Uncontrolled Asthma (PERSIST ASTHMA-1)NCT07780643GSK5784283Phase 3Not yet scoredOngoingNot yet recruiting514 est.15 Feb 2029
PERSISTCRSwNP2A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) Compared With Placebo in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)NCT07782957GSK5784283Phase 3Not yet scoredOngoingNot yet recruiting218 est.6 Mar 2029
PERSISTCRSwNP1A Study to Assess the Efficacy and Safety of GSK5784283 (Felcorekibart) in Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)NCT07782970GSK5784283Phase 3Not yet scoredOngoingNot yet recruiting218 est.6 Mar 2029
PALISADELong-term Follow-up of Long-acting Cabotegravir (CAB LA) for PrEP (Pre-exposure Prophylaxis) in Participants at Risk of Acquiring HIV (Human Immunodeficiency Virus)NCT06134362CAB LAPhase 3Locked · track to revealOngoingActive, not recruiting2,996 est.14 Mar 2029
A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older AdultsNCT07628049RSV/hMPV_V low dose vaccinePhase 1Not yet scoredOngoingRecruiting1,456 est.5 Apr 2029
VIGILANTeValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 InflammationNCT07177339DepemokimabPhase 3Locked · track to revealOngoingRecruiting1,196 est.30 Apr 2029
A Study to Investigate the Efficacy and Safety of GSK5784283 Compared With Placebo in Participants With Uncontrolled Asthma (PERSIST ASTHMA-2)NCT07782996GSK5784283Phase 3Not yet scoredOngoingNot yet recruiting370 est.4 May 2029
A Study Exploring the Effect of Adjuvanted RZV or RSVPreF3 Vaccines on Coronary Plaque Progression in Adults >=50 Years of Age at Risk for Cardiovascular EventsNCT07712380Adjuvanted RZV vaccinePhase 2Not yet scoredOngoingNot yet recruiting450 est.4 May 2029
A Study to Investigate Safety, Tolerability and Pharmacokinetics of VH5356136 in Adult Participants Without HIVNCT07822477VH5356136 Formulation 1Phase 1Not yet scoredOngoingNot yet recruiting160 est.9 May 2029
A Study of Risvutatug Rezetecan in Combination With Ivonescimab in Participants With Advanced Solid Tumors (EMBOLD PanTumour-103)NCT07602855Risvutatug rezetecanPhase 1Locked · track to revealOngoingNot yet recruiting184 est.21 Jun 2029
View all trials4,008

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We check every one of its trials daily and tell you what moved.

  • Status changeStatus moved to completedWas recruiting · always alerts
  • Completion date movePrimary completion slipped 210 daysSlips and pull-ins of 30+ days
  • New trialNew trial registered in your scopeFirst posted within 30 days
  • Enrollment changeEnrollment grew to 1,200Moves of 15%+ or count finalised
  • Substantive record editPrimary endpoint redefined from 24 to 52 weeksRead overnight and flagged in plain English
US registryClinicalTrials.gov
EU registryCTIS · Soon
4,008

Trials as lead sponsor

84

Recruiting now

983

Phase 3 trials

946

Phase 2 trials

1,266

Phase 1 trials

343

Phase 4 trials